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DNA由A、G、C、T四个核苷构成。科学家在DNA序列中经常发现许多替代这四个正常字母的变体，它们通常能够帮助细胞控制基因开关，被称为“表观遗传标记”。以往科学家只能在偶然情况下发现这些变体。而据美国麻省理工学院（MIT）近日消息称，该校和佛罗里达大学及其他机构研究人员开发出一套先进的技术平台，能有系统地发现未知的表观遗传标记和变体。
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disea...
Researchers shed new light on regulation of repetitive DNA sequences
Researchers repetitive DNA sequences
2016/2/22
A pair of studies by a team of scientists has shed new light on the nature of a particular type of DNA sequences—tandem DNA repeat arrays—that play important roles in transcription control, genome org...
青岛科技大学DNA合成方法取得突破
青岛科技大学 DNA合成方法
2015/11/13
日前，青岛科技大学化学与分子工程学院马翠萍课题组发现了几种DNA聚合酶具有内在的反转录酶活性，突破了DNA聚合酶只能以DNA为模板合成DNA的传统认知，对RNA的快速检测具有重要意义。该成果在线发表于《美国化学会志》。
中国科学院昆明动物研究所在猪lincRNA基因DNA甲基化研究中取得新进展
中国科学院昆明动物研究所 基因
2015/10/30
猪和人类有相似的心血管系统、代谢特征和器官大小。因此，近些年猪逐渐成为研究能量代谢、人类肥胖和器官移植的理想医学动物模型。数千年的人工选择已经使家猪具有了巨大的表型多样性，例如，不同的品种猪的脂肪和肌肉含量有很大的差异。因此，这些品系是研究脂肪沉积和肌肉发育的很好的模型。LincRNA是一类长链非编码RNA，在包括转录调控的多个生物学过程中发挥调控作用。在之前的研究中，科学家鉴定了4515个猪基因...
The MinION, a handheld DNA-sequencing device developed by Oxford Nanopore, has been tested and evaluated by an independent, international consortium coordinated by EMBL’s European Bioinformatics Insti...
2015年9月22日，《Nucleic Acids Research》（《核酸研究》，IF: 9.112）在线发表了华中农业大学农业微生物学国家重点实验室何璟教授团队关于药物抗性机制方面的最新研究成果。论文以“Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduct...
视频：内蒙古大学生命科学学院基因工程 DNA序列分析教学录像。
Researchers Use DNA‘Clews’to Shuttle CRISPR-Cas9 Gene-Editing Tool into Cells
Researchers DNA Clews Shuttle CRISPR-Cas9 Gene-Editing Tool
2015/9/8
CRISPR–Cas9 represents a promising platform for genome editing, yet means for its safe and efficient delivery remain to be fully realized. A novel vehicle that simultaneously delivers the Cas9 protein...
2015年8月21日，中国科学院上海生命科学研究院上海植物逆境生物学研究中心研究员杜嘉木在国际学术期刊Nature Reviews Molecular Cell Biology上发表了题为DNA methylation pathways and their crosstalk with histone methylation 的第一作者综述论文。该文系统性地总结了近年来在DNA甲基化和组...
How DNA ‘Proofreader’ Proteins Pick and Edit Their Reading Material
DNA Proofreader Proteins Pick Reading Material
2015/9/9
DNA mismatch repair (MMR) identifies and corrects errors made during replication. In all organisms except those expressing MutH, interactions between a DNA mismatch, MutS, MutL, and the replication pr...
Regulocator: A Novel Method for the Identification of Conserved Elements in Genomic DNA
ReguLocator DNA Conserved Elements
2015/5/26
The process of generating RNA message from a gene is termed "transcription," and is performed by aptly named "transcription factors." These transcription factors can function singly or in conjunction ...
Abstract
Timothy E. Breen Ph.D.
A DATABASE FOR NUCLEAR RECEPTOR DNA BINDING SITES
A database has been developed for nuclear receptor DNA binding sites and the corresponding nuclear receptor DNA ...
Metnase is a novel bifunctional protein that contains a SET domain and a transposase domain. Metnase contains sequence-specific DNA binding activity and sequence non-specific DNA cleavage activity, as...