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Randomized Controlled Trials (RCTs) are currently the gold standard within evidence-based medicine. Usually, they are conducted as sequential trials allowing for monitoring for early signs of effectiv...
Philosophers subscribing to particular principles of statistical inference need to be aware of the limitations and practical consequences of the statistical approach they endorse. The framework here p...
It is commonly believed that when a finite value is received in a game that has an infinite expected value, it is in one’s interest to redo the game (note that switching to an unknown but already dete...
This paper analyzes statistical decisions during the interim analyses of clinical trials. After some general remarks about the ethical and scientific demands of clinical trials, I introduce the notion...
Background South Africa is likely to be the first country in the world to host an adolescent HIV vaccine trial. Adolescents may be enrolled in late 2007. In the development and review of adolescent H...

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