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Targeted Editing of Myostatin Gene in Sheep by Transcription Activator-like Effector Nucleases
Myostatin Targeted Gene Editing Sheep Primary Fibroblasts
2016/5/19
Myostatin (MSTN) is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Gene knockout of MSTN can result in increasing muscle mass ...
Myostatin三维结构模建及分子进化分析
肌肉生长抑制素基因 分子进化 同源模建
2009/7/2
Myostatin(MST)为肌肉生长负调节因子，其功能受抑制可导致肌肉量增加。对MST核酸序列进行序列比对，构建进化树；采用同源模建方法首次模建MST成熟肽生物活性二聚体的四级结构，并预测MST与其受体ActRIIB的相互作用模式。进化树将肌肉生长抑制素基因（MSTN）分成4个亚家族：哺乳动物MSTN，鸟类MSTN以及鱼类MSTN 1和2。MST受纯化选择作用，在不同物种的直系同源基因具有较高...
Effects of Castration on Androgen Receptor, IGF-I Ea, MGF and Myostatin Gene Expression in Skeletal Muscles of Male Pigs
Pig Castration Skeletal Muscle Molecular Cloning Gene Expression
2016/4/29
Castration of male pig produces significant negative effects on skeletal muscle development. The androgen receptor (AR), two splice variants of insulin-like growth factor-I (IGF-I Ea and MGF) and the ...
Effect of Thyroid Hormone on the Gene Expression of Myostatin in Rat Skeletal Muscle
Thyroid Hormone Skeletal Muscle Hyperthyroidism Hypothyroidism Myostatin Expression
2016/4/29
Modification of thyroid hormone levels has a profound effect on skeletal muscle differentiation, predominantly through direct regulation involving thyroid hormone receptors. Nevertheless, little is kn...
Association of SNP Haplotypes at the Myostatin Gene with Muscular Hypertrophy in Sheep
Double Muscle SSCP Phenotype Haplotype
2016/4/28
The myostatin gene of seven important meat (Beltex (Australia), BeltexHuyang (F1), Meat and Multi-Prolific Chinese Merino Fine Wool, Meat Chinese Merino Fine Wool and Dorper (South Africa)) an...
进行性肌营养不良患者Myostatin基因的表达分析
进行性肌营养不良 肌肉抑制素基因 蛋白加工
2008/1/30
摘要进行性肌营养不良是一组以进行性骨骼肌萎缩和无力为特征的肌源性肌病。肌肉抑制素（Myostatin）是最近发现的骨骼肌生长发育抑制因子。为探讨Myostatin基因与进行性肌营养不良病理发生的相关性，采用RT-PCR方法克隆了患者的Myostatin基因并测序，分析肌营养不良患者是否存在Myostatin基因突变；然后采用半定量RT-PCR方法检测患者中Myostatin基因的表达水平是否发生改...
鸡Myostatin基因单核苷酸多态性的群体遗传学分析
鸡 Myostatin基因 单核苷酸多态性
2008/1/29
摘要肌肉生长抑制素是控制骨骼肌生长发育的重要细胞因子,采用PCR-SSCP和测序的方法发现了5个位于Myostatin基因5'-和3'-调控区的单核苷酸多态性位点,对北京油鸡、白耳鸡、石歧杂、矮小黄鸡、小型黄鸡、惠阳胡须鸡、隐性白羽鸡、海兰、AA鸡等不同鸡种的该单核苷酸多态性分析结果表明:Myostatin基因的5'调控区引物P60/P61扩增片段多态性是由3个核苷酸的改变而产生的[分别是G→A(...
野猪及其与家猪杂种猪Myostatin 基因3’编码区的克隆和序列分析
2007/10/31
题目：野猪及其与家猪杂种猪Myostatin 基因3’编码区的克隆和序列分析
作者：刘娣 杨秀芹 杨甲芳 张向吉吉 马建章
东北农业大学动物科技学院
关键词：Myostatin 基因; 野猪; 野猪与家猪的杂种猪; 序列分析
Cloning and Prokaryotic Expression of the Mature Fragment of the Chinese Yellow Bovine Myostatin Gene
Prokaryotic Expression Chinese Yellow Bovine Myostatin Gene
2016/4/25
Myostatin is a member of the transforming growth factor-??(TGF-?? super-family. It acts as a negative regulator for skeletal muscle growth. Myostatin mutations are characterized by a visible, generali...
Suppressed Cell Proliferation and Differentiation Following an Over-expression of Myostatin is Associated with Inhibited Expression of Insulin-like Growth Factor II and Myogenin in Rat L6 Myoblasts
Myostatin IGF Myogenin Myoblast Proliferation Differentiation
2016/4/22
Myostatin (MSTN) and insulin-like growth factors (IGFs) are a known inhibitor and stimulators of proliferation and differentiation of muscle cells, respectively. The present study was performed to inv...
Effect of Maternal Passive Autoimmunization against Myostatin on Growth Performance in Chickens
Myostatin Autoimmunization Muscle Growth Chicken
2016/4/19
Myostatin is a negative regulator of skeletal muscle growth and a loss of functional myostatin protein increases muscle hypertrophy and hyperplasia in cattle. The present study was conducted to invest...
Associations of T→A Mutation in the Promoter Region of Myostatin Gene with Birth Weight in Yorkshire Pigs
Pig Myostatin Gene Mutation Birth Weight
2016/4/12
A T->A mutation in the promoter region of porcine myostatin (MSTN) gene has been identified in our previous work. This study analyzed the associations of the myostatin genotypes (TT, TA) caused by thi...