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The Effects of Glucagon-like Peptide-2 on the Tight Junction and Barrier Function in IPEC-J2 Cells through Phosphatidylinositol 3-kinase–Protein Kinase B–Mammalian Target of Rapamycin Signaling Pathway
Transepithelial Electrical Resistance Phosphatidylinositol 3-Kinase-Akt-mTOR Signaling Pathway
2016/5/20
Glucagon-like peptide-2 (GLP-2) is important for intestinal barrier function and regulation of tight junction (TJ) proteins, but the intracellular mechanisms of action remain undefined. The purpose of...
Rapamycin Rescues the Poor Developmental Capacity of Aged Porcine Oocytes
Reactive Oxygen Species (ROS) Mammalian Target of Rapamycin (mTOR)
2016/5/16
Unfertilized oocytes age inevitably after ovulation, which limits their fertilizable life span and embryonic development. Rapamycin affects mammalian target of rapamycin (mTOR) expression and cytoskel...
生物体的衰老（aging）是一个非常复杂的过程。随着年龄的增长，生物体内各种分子、细胞、组织以及器官的损伤会不断的积累，从而逐渐丧失功能，并最终导致疾病和死亡。近年来，延缓衰老以及延长人类的健康寿命（healthy lifespan）成为了生物学研究的热点。包括mTOR以及IIS信号通路在内的一些细胞信号通路已经被证明与生物体的寿命调节有着密切的联系。中科院上海生命科学研究院生化与细胞所裴钢课题组...