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Two new requirements for producing normal ribosomes: (I) A novel helicase is needed for snoRNP biogenesis, and; (II) Pseudouridine modifications in the reaction center are important for ribosome function
Eukaryotic cells contain protein particles ribosomes RNA nucleotide pseudouridine
2014/12/11
Eukaryotic cells contain scores of small nucleolar RNAs (snoRNAs) that are complexed with proteins in particles known as snoRNPs. SnoRNPs function in processing of ribosomal RNA (rRNA) and nucleotide ...
Probing the Peptidyl Transferase Center of Ribosomes Containing Mutant 23S rRNA with Photoreactive tRNA
ribosome peptidyl transferase center photoreactive crosslinking tRNA 23S rRNA translation
2014/12/9
There is strong crystallographic evidence that the 23S rRNA is the only catalytic entity in the peptidyl transferase center. Various mechanisms for the catalysis of peptidyl transfer have been propose...