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摘要采用mRNA原位双杂交和免疫组织化学方法对31例非小细胞肺癌组织进行p1611NK4、Rb基因表达水平及其相关性的研究。结果显示,以Dig-碱性磷酸酶-NBT/BCIP系统检测p16INK4基因转录,阳性结果呈蓝色,阴性杂交率为22.6%(7/31);以Bio-辣根过氧化物酶-AEC系统检测Rb基因转录,阳性结果为红色,阴性率为16.1%(5/31)。免疫组织化学检测显示p161NK4蛋白质阴...
Rb基因在人胃癌中异常的初步观察
人胃癌组织 Rb基因 缺失 Southern印迹杂交
2007/12/20
摘要 Rb基因是一种抗癌基因,其产物Rb蛋白与细胞转化、细胞周期调节及转录调控有密切关系。许多肿瘤如视网膜母细胞瘤、乳腺癌、小细胞肺癌、前列腺癌、膀胱癌、骨肉瘤、软组织肉瘤等,都与Rb基因的失活或缺失有关。胃癌是消化道常见多发肿瘤,研究表明,其发生发展与多种癌基因的活化、抗癌基因的异常有关。我们用Southern印迹杂交法,以Rb基因为探针,检测了九例胃癌患者的癌组织和一个胃癌细胞株,发现它们与正...
p53、Rb、IGF-I、AT1B基因转移对血管新生内膜增殖的影响
2007/7/25
30%~50%的血管再狭窄发生率是影响冠心病介入治疗远期疗效的主要因素[1]。血管平滑肌细胞迁移至内膜并过度增殖所致的新生内膜增厚是发生再狭窄的关键[2]。野生型p53 基因可调节细胞的生长、复制和死亡[3]；Rb蛋白是细胞周期调控和细胞分化中重要的转录调节因子，处于细胞生长、分化的中心环节；胰岛素样生长因子(Insulin-like growth factor, IGF)是一类具有胰岛素样生长刺...
Determination of the Toxicities of Fenpropathrin (Pyrethroid) and Neem Formulation (RB-a+PBO+Tx-100) Against Alphitobius diaperinus Adults and Their Effects on Transaminases
Toxicity Pyrethroid Azadirachta indica Transaminases Alphitobius
2010/4/1
This report describes the determination of the toxicity of two pesticides, neem formulation (RB-a+PBO+Tx-100) and fenpropathrin, on Alphitobius diaperinus adults. The mortalities caused by the two com...
Comparative Toxicological Studies of RB-a (Neem Extract) and Coopex (Permethrin+Bioallethrin) Against Sitophilus oryzae With Reference to Their Effects on Oxygen Consumption and Got, Gpt Activity
Comparative Toxicological Studies RB-a (Neem Extract) Coopex (Permethrin+Bioallethrin)
2010/4/1
The toxicity of a neem extract RB-a in comparison with a pyrethroid, Coopex, was studied along with their effects on GPT and GOT activities and oxygen consumption in S. oryzae. The LD 50 value of Coop...
Comparative Toxicological Studies of RB-a (Neem Extract) and Coopex (Permethrin+Bioallethrin) Against Sitophilus oryzae With Reference to Their Effects on Oxygen Consumption and Got, Gpt Activity
Comparative Toxicological Studies RB-a (Neem Extract) Coopex (Permethrin+Bioallethrin)
2010/4/1
The toxicity of a neem extract RB-a in comparison with a pyrethroid, Coopex, was studied along with their effects on GPT and GOT activities and oxygen consumption in S. oryzae. The LD 50 value of Coop...