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Longitudinal study of alcohol consumption and HDL concentrations: a community-based study
alcohol cardiovascular disease risk epidemiology HDL lipids prospective cohort triglyceride
2018/11/13
Background: In cross-sectional studies and short-term clinical trials, it has been suggested that there is a positive dose-response relation between alcohol consumption and HDL concentrations. However...
Study refutes how fruit flies developed alcohol tolerance
Study refutes fruit flies alcohol tolerance
2017/2/16
More than two decades ago, in one of the first papers using gene sequences to find signatures of natural selection, scientists hypothesized that a molecular change in an enzyme gave the Drosophila mel...
TRANSCRIPTIONAL REGULATION OF THE HUMAN ALCOHOL DEHYDROGENASES AND ALCOHOLISM
exon arrays differential gene expression alternative splicing
2015/5/25
Alcohol dehydrogenase (ADH) genes encode proteins that metabolize ethanol to acetaldehyde. Humans have seven ADH genes in a cluster. The hypothesis of this study was that by controlling the levels of ...
Kinetic Analysis of Primate and Ancestral Alcohol Dehydrogenases
alcohol dehydrogenase ADH primate evolution
2015/5/25
Seven human alcohol dehydrogenase genes (which encode the primary enzymes involved in alcohol metabolism) are grouped into classes based on function and sequence identity. While the Class I ADH isoenz...
Identification of genes affected by fetal alcohol exposure during brain development
The fetus alcohol mental retardation injury mechanism the brain genes and animal models
2014/12/11
Fetal alcohol exposure is the leading known cause of mental retardation in the western world. However, the mechanisms underlying alcohol-induced damage in fetal brain are largely unknown. The goal of ...
Epigenetic alteration by prenatal alcohol exposure in developing mouse hippocampus and cortex
Epigenetic alteration Epigenetics
2015/5/21
Fetal alcohol spectrum disorders (FASD) is the leading neurodevelopment deficit in children born to women who drink alcohol during pregnancy. The hippocampus and cortex are among brain regions vulnera...
Molecular and Cellular Mechanisms Leading to Similar Phenotypes in Down and Fetal Alcohol Syndromes
Down Syndrome Fetal Alcohol Syndrome Caspase 3 Dyrk1a Rcan1 Akt
2015/5/22
Down syndrome (DS) and Fetal Alcohol Syndrome (FAS) are two leading causes of birth defects with phenotypes ranging from cognitive impairment to craniofacial abnormalities. While DS originates from th...