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分子发育生物学国家重点实验室田烨研究组应邀在Trends in Biochemical Sciences撰写“线粒体-细胞核交流通过表观调控衰老”的综述文章（图）
分子发育生物学国家重点实验室 田烨 Trends in Biochemical Sciences 线粒体 细胞核 衰老
2022/4/22
线粒体的蛋白质组由细胞核和线粒体DNA(mtDNA)共同编码，维持线粒体与细胞核之间的交流对于线粒体的功能十分重要。衰老过程通常伴随着线粒体氧化磷酸化活性降低、TCA循环相关酶含量下降、mtDNA突变累积、活性氧增加，以及线粒体蛋白稳态的失衡。这些变化会影响线粒体与细胞核之间的交流，导致基因表达的变化并影响衰老进程。 线粒体不仅是能量代谢、生物合成的中心，其作为信号转导中心在调控细胞功...
北京大学生命科学学院陆剑实验室在Trends in Biochemical Sciences撰写综述总结uORF的功能和演化规律（图）
北京大学生命科学学院 陆剑 实验室 Trends in Biochemical Sciences uORF功能 演化规律
2019/4/23
2019年4月17日，北京大学生命科学学院、蛋白质与植物基因研究国家重点实验室成员陆剑研究员受邀在分子生物学综述类知名期刊《生物化学趋势》（Trends in Biochemical Sciences）发表题为“真核生物上游开放阅读框的功能与演化”（Function and Evolution of Upstream ORFs in Eukaryotes）的综述文章，总结了uORF的最新研究进展以...
Effects of different durations of fasting/re-feeding bouts on growth, biochemical and histological changes in the digestive tract of Ganus golden trout (Oncorhynchus mykiss)
biochemistry food deprivation phenotypic changes histology productive traits
2018/11/23
This study was conducted to explore the outcomes of starvation/re-feeding techniques on growth performance, liver antioxidant activities, and histological changes of the gastrointestinal organs of Gan...
Electronic circuits are found in almost everything from smartphones to spacecraft and are useful in a variety of computational problems from simple addition to determining the trajectories of interpla...
Biochemical Characterization and Electron-Transfer Reactions of sym1,a Rhodobacter capsulatus Reaction Center Symmetry Mutant which Affects the Initial Electron Donor
Biochemical Characterization Electron-Transfer Reactions sym1 Rhodobacter capsulatus Reaction Center Initial Electron Donor
2016/5/23
A 51 bp section of the Rhodobacter capsulatus photosynthetic reaction center M subunit gene (nucleotides M562-M612 of the pufM structural sequence) encoding amino acids M187-M203 was replaced by the h...
Characterization of a fatty acid elongase condensing enzyme by site-directed mutagenesis and biochemical analysis
ELONGASE CONDENSING ENZYME
2015/5/21
Fatty acid elongation is the extension of de novo synthesized fatty acids through a series of four reactions analogous to those of fatty acid synthase. ELOs catalyze the first reaction in the elongati...
Seeking the primary sense: A biochemical and biophysical study of the signaling mechanism of bacterial chemotaxis
Genetics biochemistry biophysics membrane cytoplasmic proteins bacteria and chemical serine receptors e. coli
2014/12/11
Genetic, biochemical, and biophysical methods have been adopted to characterize the interactions between ligand and transmembrane receptor, between receptor and cytoplasmic proteins, and between cytop...
The building of a centromeric nucleosome: Biochemical analysis and comparison of Cse4p, histone H3 and Cse4-286p to define the unique assembly pathway of a Cse4p nucleosome
Nucleosome chromatin structure octamer core protein chromatin structure cell nuclear cells the cellular mechanisms
2014/12/11
Nucleosomes are the most fundamental unit of chromatin structure, which is composed of ~～145 bp of DNA wrapped around an octamer of core histones H2A, H2B, H3 and H4. Chromatin structure plays a role ...
Structural And Biochemical Studies Of The Human Lysosomal Enzymes: N-Acetylgalactosamine-6-Sulfatase, N-Sulfoglucosamine Sulfohydrolase And Beta-Galactosidase
Pure sciences Biological sciences Cysteine modification Enzyme replacement therapy Lysosomal storage disease Pharmacological chaperone therapy Sulfatase structure X-ray crystallography
2014/12/10
Lysosomal storage diseases are disorders caused by deficiencies of enzymes responsible for the degradation of substances present in lysosomes. The loss of activity of a lysosomal enzyme leads to the a...
Influence of PEG generated osmotic stress on shoot regeneration and some biochemical parameters in Lathyrus culture
drought grass pea in vitro screening multiplication rate proline
2014/7/9
Several Lathyrus species and in particular Lathyrus sativus (grass pea) display much tolerance to drought and have great agronomic potential as grain and forage legumes. Studies on these crop species ...
Changes in Hematological, Biochemical and Non-specific Immune Parameters of Olive Flounder, Paralichthys olivaceus, Following Starvation
Biochemical Response Lysozyme Activity Food Deprivation
2016/5/17
Triplicate groups of fed and starved olive flounder, Paralichthys olivaceus (body weight: 119.8±17.46 g), were examined over 42 days for physiological changes using hematological, biochemical, and non...
Deletion of the Lmna Gene Induces Growth Delay and Serum Biochemical Changes in C57BL/6 Mice
Lmna Deficient Mice Growth Delay Serological Changes
2016/5/16
The A-type lamin deficient mouse line (Lmna−/−) has become one of the most frequently used models for providing insights into many different aspects of A-type lamin function. To elucidate ...
中国科学院上海生命科学研究院许琛琦研究员受邀在Trends in Biochemical Sciences发表综述论文
许琛琦研究员 Trends in Biochemical Sciences 酸性磷脂 细胞生物学
2014/3/12
近日，中国科学院生物化学与细胞生物学研究所/国家蛋白质科学中心·上海(筹)许琛琦研究员受邀在Cell 出版社综述期刊 Trends in Biochemical Sciences 上在线发表题为“Ionic protein-lipid interaction at the plasma membrane what can the charge do?”的科研综述，该综述论文总结了酸性磷脂领域的最新...
Effects of Dietary Electrolyte Balance on Growth Performance, Nitrogen Metabolism and Some Blood Biochemical Parameters of Growing Rabbits
Dietary Electrolyte Balance Growing Rabbit Growth Performance Nitrogen Metabolism
2016/5/16
The effects of different dietary electrolyte balance (DEB) on growth performance, nitrogen (N) metabolism and some blood biochemical parameters were investigated in 2 to 3 months old growing rabbits. ...
Preliminary Comparative Physiological and Biochemical Study of Five Different Goat Breeds Inhabiting Saudi Arabia
Goat Breeds Electrophoresis Isoenzymes Physiology Saudi Arabia
2013/3/8
Three arbitrary chosen enzymes were examined by native-polyacrylamide gel electrophoresis to investigate physiological and genetic variations among five different goat breeds inhabiting Saudi Arabia. ...