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3 Questions: A new model of nervous system form, function, and evolution（图）
神经系统形态 神经科学模型 Brady·Weissbourd
2023/6/5
How does animal behavior emerge from networks of connected neurons? How are these incredible nervous systems and behaviors actually generated by evolution? Are there principles shared by all nervous s...
With plants as a model, studying the ‘complexity and reproducibility’ of developmental biology（图）
植物 发育生物学 分子机制
2023/7/11
Nearly paper-thin, often with a complex two-dimensional shape, leaves may number into the hundreds of thousands on an organism like a white oak. Yet typically, each leaf appears quite similar in form.
One reason it's so difficult to produce effective vaccines against some viruses, including influenza and HIV, is that these viruses mutate very rapidly. Mutation allows them to evade the antibodies ge...
Model could improve design of vaccines, immunotherapies（图）
Model improve design vaccines immunotherapies
2020/11/6
The body's immune system defeats diseases by sensing foreign invaders, such as bacteria or viruses, then mounting a response against them.But how immune cell receptors work together to sense multiple ...
Model predicts bat species with potential to spread Nipah virus（图）
Model predicts bat species potential spread Nipah virus
2019/10/23
Since its discovery in 1999, Nipah virus has been reported almost yearly in Southeast Asia, with Bangladesh and India the hardest hit. In a new study, published in PLOS Neglected Tropical Diseases, sc...
New computer model shows how proteins are controlled “at a distance”
New computer model shows proteins controlled at a distance
2017/3/14
Enzymes are large proteins that are involved in virtually every biological process, facilitating a multitude of biochemical reactions in our cells. Because of this, one of the biggest effort...
Model expands landscape for signaling protein mutations
Model expands landscape signaling protein
2016/11/4
Protein pairs that control stimulus response in bacteria maintain a sensitive balance between interaction specificity and promiscuity, according to Rice University scientists.A computational model dev...
Neurodevelopmental model of Zika may provide rapid answers
Neurodevelopmental model Zika rapid answers
2016/11/4
A newly published study from researchers working in collaboration with the Regenerative Bioscience Center at the University of Georgia demonstrates fetal death and brain damage in early chick embryos ...
Scientists model outer membrane of 12 bacterial species to speed new drugs for 'bad bugs'
Scientists model membrane 12 bacterial species speed new drugs bad bugs
2016/11/4
As bacteria change their behavior to foil the drugs designed to kill them, illnesses that were once relatively easy to treat become difficult to cure. The phenomenon is known as antibiotic resistance,...
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development
birth defects developmental defects embryo folic acid high folate methylenetetrahydrofolate reductase MTHFD1 placenta
2018/12/19
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydro...
Therapeutic brain modulation with targeted large neutral amino acid supplements in the Pah-enu2 phenylketonuria mouse model
phenylketonuria inborn error of metabolism large neutral amino acids mouse model neurotransmitters brain biochemistry treatment
2018/12/18
Background: Phenylketonuria treatment consists mainly of a Phe-restricted diet, which leads to suboptimal neurocognitive and psychosocial outcomes. Supplementation of large neutral amino acids (LNAAs)...
Estimation of Genetic Parameters for First Lactation Monthly Test-day Milk Yields using Random Regression Test Day Model in Karan Fries Cattle
Test-day Milk Yield Random Regression Model Heritability Genetic Correlation Karan Fries Cattle
2016/7/27
A single trait linear mixed random regression test-day model was applied for the first time for analyzing the first lactation monthly test-day milk yield records in Karan Fries cattle. The test-day mi...
Random Regression Models Are Suitable to Substitute the Traditional 305-Day Lactation Model in Genetic Evaluations of Holstein Cattle in Brazil
Legendre Polynomials 305-Day Milk Yield Breeding Values Reliability Brazilian Holstein
2016/7/27
The aim of this study was to compare two random regression models (RRM) fitted by fourth (RRM4) and fifth-order Legendre polynomials (RRM5) with a lactation model (LM) for evaluating Holstein cattle i...
Model Membrane Systems and Their Applications
SUPPORTED LIPID-BILAYERS ION MASS-SPECTROMETRY GIANT UNILAMELLAR VESICLES MOLECULAR-DYNAMICS BIOLOGICAL-MEMBRANES PHASE-SEPARATION PROTEINS FUSION RECONSTITUTION SIMULATION
2016/5/25
The complexity of biological membranes has motivated the development of a wide variety of simpler model systems whose size, geometry, and composition can be tailored with great precision. Approaches h...
E-Cadherin Tethered to Micropatterned Supported Lipid Bilayers as a Model for Cell Adhesion
E-Cadherin Tethered Micropatterned Lipid Bilayers Cell Adhesion
2016/5/24
Cell-cell adhesion is a dynamic process requiring recruitment, binding, and reorganization of signaling proteins in the plane of the plasma membrane. Here, we describe a new system for investigating h...