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One reason it's so difficult to produce effective vaccines against some viruses, including influenza and HIV, is that these viruses mutate very rapidly. Mutation allows them to evade the antibodies ge...
Model could improve design of vaccines, immunotherapies（图）
Model improve design vaccines immunotherapies
2020/11/6
The body's immune system defeats diseases by sensing foreign invaders, such as bacteria or viruses, then mounting a response against them.But how immune cell receptors work together to sense multiple ...
Using the mouse egg as a model system for the study of intracellular calcium signaling mechanisms
Oscillation eggs fertilization cell model system inositol
2014/12/11
Mouse metaphase II (MII)-stage eggs exhibit oscillatory Ca2+ responses ([Ca2+]i oscillations) following fertilization. The wealth of information regarding Ca2+ signaling pathways in eggs has allowed t...
Genetic studies of the regulation of RecA activity in Escherichia coli: A two filament model
E. coli protein compound enzyme DNA repair bacteria
2014/12/11
The RecA protein of Escherichia coli is a central enzyme in recombination and SOS induction, both crucial DNA repair pathways. Furthermore, RecA and its homologues are found in all domains of life, fr...
From Mouse Mammary Tumor Model to New Therapeutic Method ---Mammary Tumor Development in Balb/c-Trp53+/- Mice and Magnetic Nanoparticle Induced Heating for Cancer Treatment
Breast cancer Magnetic nanoparticle Mammary gland Mouse tumor model Stem cell Thermotherapy
2014/12/10
PATHWAYS CONTRIBUTING TO DEVELOPMENT OF SPONTANEOUS MAMMARY TUMORS IN BALB/c-Trp53+/- MICE Mutation and loss of p53 function are common features among human breast cancers. We use BALB/c-Trp53+/- mice...
Model of viral lifecycle could help in finding a cure for hepatitis B（图）
viral lifecycle cells immune response
2014/8/19
A new technique for studying the lifecycle of the hepatitis B virus could help researchers develop a cure for the disease.
In a paper published today in the journal Proceedings of the National Academ...
TRP-1 AS A MODEL TUMOR ANTIGEN FOR IMMUNOTHERAPY AND IMMUNE TOLERANCE IN THE THYMUS
immune tolerance T cells mTECs
2015/5/21
Tolerance mechanisms, which collectively work to prevent autoimmunity, play a key role in suppressing the adaptive immune response to tumor antigens. This phenomenon is attributed to the extensive ove...
A Structured Population Model of Cell Differentiation
Structured Population Model Cell Differentiationv
2011/1/5
We introduce and analyze several aspects of a new model for cell differentiation. It assumes that differentiation of progenitor cells is a continuous process. From the mathematical point of view, it i...
Viral epidemics in a cell culture: novel high resolution data and their interpretation by a percolation theory based model
cell culture novel high resolution data interpretation
2011/1/5
Because of its relevance to everyday life, the spreading of viral infections has been of central interest in a variety of scientific communities involved in fighting, preventing and theoretically inte...