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the KATP channels are inhibited by direct ATP binding to the Kir pore-forming subunit, preventing K+ flux across the membrane ,sarcolemma (sarcKATP) membrane the inner membrane of the mitochondria.
局部注射αβme-ATP对大鼠背部皮肤初级传入纤维的兴奋作用
2007/7/28
期刊信息
篇名
局部注射αβme-ATP对大鼠背部皮肤初级传入纤维的兴奋作用
语种
中文
撰写或编译
撰写
作者
张琪,赵晏,田雨灵,郭媛,曹东元,王会生
第一作者单位
西安交通大学医学院
刊物名称
第一军医大学学报
页面
5
出版日期
2005年
10月
日
文章标识(ISSN)
1000-2588
相关项目
膀胱经穴位之间联系的递质及受体机理
T he relative order of mK channels, free radicals and p38 MAPK in ATP preconditioning’s protective pathway in rat heart
Free radicals Infarction Ischemia Mitochondria Preconditioning Signal transduction
2014/3/31
Ischemic preconditioning (PC) reduces myocardial infarction by a mechanism that involves opening of mitochondrial
ATP-dependent potassium channels (mK ), reactive oxygen species (ROS), and possibly a...
Activation of Mitochondrial ATP-Dependent Potassium Channels by Nitric Oxide
ischemic preconditioning nitric oxide myocytes mitochondria
2014/3/31
We measured mitochondrial redox potential as an index of mitoKATP
channel opening in rabbit
ventricular myocytes. The NO donor S-nitroso-N-acetyl- DL-penicillamine (SNAP, 0.1 to 1 mmol/L) oxidized t...
Mitochondrial ATP-Sensitive Potassium Channel Activation Protects Cerebellar Granule Neurons From Apoptosis Induced by Oxidative Stress
Mitochondrial ATP-Sensitive Oxidative Stress
2014/3/31
ptosis contributes to ischemic injury in the brain,
4
and
brain mitochondria contain 7 times more mitoK
ATP
channels
than heart mitochondria.
5
Several reports have shown that
mitoKATP
chann...
Investigation of the subunit compositi on and the pharmacology of the mitochondrial ATP-dependent K + channel in the brain
ATP-dependent potassium channel Ischemic preconditioning Mitochondrial nitric oxide synthase mtNOS Sulfonylurea recepto
2014/3/31
Selective activation of mitoK
AT P
channels can protect the brain or cultured neurons against a variety of anoxic or metabolic challenges.
However, little is known about the subunit composition or ...