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Excess iron: considerations related to development and early growth
brain early growth erythropoiesis excess iron iron metabolism ron toxicity pregnancy stem cells
2018/11/21
What effects might arise from early life exposures to high iron? This review considers the specific effects of high iron on the brain, stem cells, and the process of erythropoiesis and identifies gaps...
MU Study Finds that Gravity,‘Mechanical Loading’ are Key to Cartilage Development
MU Study Gravity Mechanical Loading Cartilage Development
2017/9/5
Mechanical loading, or forces that stimulate cellular growth for development, is required for creating cartilage that is then turned to bone; however, little is known about cartilage development in th...
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development
birth defects developmental defects embryo folic acid high folate methylenetetrahydrofolate reductase MTHFD1 placenta
2018/12/19
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydro...
Effects of maternal and child lipid-based nutrient supplements on infant development: a randomized trial in Malawi
cognitive development iLiNS project infant development lipid-based nutrient supplements maternal micronutrient supplements
2018/11/28
Background: Maternal and infant undernutrition is associated with poor infant development; however, few studies have examined the impact of combined pre- and postnatal dietary supplementation on infan...
THE HAND1 LINEAGE REVEALS DISTINCT ROLES FOR HAND FACTORS DURING CARDIOVASCULAR DEVELOPMENT
Development Gene expression
2015/5/21
The basic Helix-Loop-Helix (bHLH) transcription factors Hand1 and Hand2 play critical roles in the development of multiple organ systems during embryogenesis. The dynamic expression patterns of these ...
骨与关节系统发生过程中相关调控机制的研究进展Progress on the related mechanism in the development of bone and joint
发生 肢芽 间充质细胞
2008/1/10
摘要脊椎动物胚胎期骨与关节系统的发生是一种复杂生命现象，起始于中胚层间充质细胞的定向聚集，形成肢芽，然后在一系列作用因子的调控下，肢芽内细胞进一步分化，形成具有骨骼雏形的软骨原基，后者经软骨内骨化发育成骨。四肢骨大多是以这种方式发生的，四肢的滑膜关节系统也随骨骼的发生而形成。详细阐述了近年来对肢体骨与关节系统发生各步骤相关调控机制方面的研究进展。Abstract: The embryonic de...