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中国科学院上海营养与健康研究所Andrew Teschendorff研究组和汪思佳研究组首次通过Meta分析阐述血液中细胞特异性的DNA甲基化改变（图）
Meta 血液 细胞特异性 DNA甲基化
2020/9/24
2020年9月22日，国际期刊Nature Communications在线发表了中国科学院上海营养与健康研究所（中国科学院-马普学会计算生物学伙伴研究所）Andrew Teschendorff课题组与汪思佳课题组合作的题为“A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific sm...
溃疡性结肠炎患者巨细胞病毒感染或再激活危险因素的Meta分析
溃疡性结肠炎 巨细胞病毒 危险因素 Meta分析
2020/3/10
探讨溃疡性结肠炎(ulcerative colitis, UC)患者发生巨细胞病毒(cytomegalovirus, CMV)感染或再激活的危险因素。计算机检索英文数据库PubMed、Cochrane、Embase及中文数据库中国知网(CNKI)、万方数据知识服务平台(Wanfang)、中国生物医学文献服务系统(SinoMed)与维普期刊资源整合服务平台(VIP)，收集2017年3月之前国内外公开...
探讨亚洲黄种人炎症性肠病（IBD）患者硫嘌呤甲基转移酶（TPMT）基因多态性与嘌呤类药物不良反应(ADR)之间的关系。方法分别以“thiopurineS-methyltransferase”、“inflammatoryboweldisease/ulcerativecolitis/crohn’sdisease”和“thiopurine/azathioprine/6-mercaptopurine”及“...
自噬相关蛋白Beclin-1在胃癌患者中表达意义的 meta 分析
自噬 Beclin-1 胃癌 meta 分析
2020/7/10
对自噬相关蛋白 Beclin-1 在胃癌组织中的表达及其与胃癌患者不同临床病理特征的相关性及其临床意义进行系统评价。方法 计算机检索 Cochrane Library、Springer Link、Web of Science、Embase、PubMed、中国知网、万方、维普等数据库建库至 2018 年 6 月 1 日前公开发表的关于胃肿瘤组织中 Beclin-1 蛋白表达及其意义的研究，由 2 名...
A systematic review and meta-analysis of nutrition therapy compared with dietary advice in patients with type 2 diabetes
dietary advice individualized nutrition therapy meta-analysis review type 2 diabetes
2018/11/21
Background: Despite recommendations, many patients with type 2 diabetes receive dietary advice from nurses or doctors instead of individualized nutrition therapy (INT) that is provided by a dietitian.
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies
cobalamin c.776G>C genetic association studies
2018/11/20
Background: Vitamin B-12 (cobalamin) deficiency may produce severe neurologic and hematologic manifestations. Approximately 20–25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is r...
A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women
isoflavone bone estrogen deficiency osteopenia osteoporosis
2018/11/19
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...
A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women
isoflavone, bone, estrogen deficiency, osteopenia, osteoporosis
2018/11/16
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...
The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials
blood pressure cardiovascular diseases insulin resistance
2018/11/16
Background: To our knowledge, the effect of magnesium supplementation on blood pressure (BP) in individuals with preclinical or noncommunicable diseases has not been previously investigated in a meta-...
Fructose replacement of glucose or sucrose in food or beverages lowers postprandial glucose and insulin without raising triglycerides: a systematic review and meta-analysis
sugar replacement, fructose, glucose, sucrose, insulin, triglycerides, diabetes, body weight
2018/11/15
Background: Conflicting evidence exists on the effects of fructose consumption in people with type 1 and type 2 diabetes mellitus. No systematic review has addressed the effect of isoenergetic fructos...
Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation
protein bone health osteoporosis bone density diet
2018/11/14
Background: Considerable attention has recently focused on dietary protein’s role in the mature skeleton, prompted partly by an interest in nonpharmacologic approaches to maintain skeletal health in a...
Effect of fructose consumption on insulin sensitivity in nondiabetic subjects: a systematic review and meta-analysis of diet-intervention trials
fructose glucose clamp glucose disposal insulin insulin resistance meta-analysis
2018/12/19
Background: High fructose consumption has been suggested to contribute to several features of metabolic syndrome including insulin resistance, but to our knowledge, no previous meta-analyses have inve...
Neonatal thyrotropin concentration and iodine nutrition status of mothers: a systematic review and meta-analysis
iodine deficiency disorder iodine nutrition maternal urinary iodine neonatal thyrotropin pregnancy postpartum heel blood sample
2018/12/19
Background: Low maternal iodine intake disturbs the thyroid function of neonates transiently or permanently.
Effects of calcium supplementation on body weight: a meta-analysis
body weight calcium meta-analysis obesity body mass index
2018/12/18
Background: Whether calcium supplementation can reduce body weight and prevent obesity remains unclear because of inconsistent reports.
Do ω-3 PUFAs affect insulin resistance in a sex-specific manner? A systematic review and meta-analysis of randomized controlled trials
adults diabetes omega-3 PUFAs DHA EPA insulin resistance insulin sensitivity
2018/12/19
Background: Evidence has suggested that omega-3 (n–3) polyunsaturated fatty acids (PUFAs) improve obesity-induced insulin resistance (IR); however, results from human intervention trials have been equ...