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Mice have long been a central part of neuroscience research, providing a flexible model that scientists can control and study to learn more about the intricate inner workings of the brain. Historicall...
近日,英国牛津大学出版社旗下的核酸及生物信息学领域权威期刊《核酸研究》(Nucleic Acids Research,IF=19.16)在线发表了中南大学湘雅医院国家老年疾病临床医学研究中心/生物信息中心李津臣教授、赵贵虎助理研究员和安徽医科大学第一附属医院贺小进教授的最新研究成果《Performance evaluation of differential splicing analysis m...
细胞内蛋白质、核酸等生物大分子可通过液-液相分离(LLPS)形成液滴样无膜结构,为各种生命活动提供区室化反应空间,提高各种生化反应效率。LLPS受多价弱相互作用驱动,这类作用力来自于蛋白内在无序区(IDR)/类朊病毒病序列(PrLD)、支架DNA或RNA分子。长链非编码RNA(Long non-coding RNA, LncRNA)可作为支架分子促进和维持无膜结构的形成,对基因转录等重要生物学事件...
H3K36甲基化是生物体内重要的组蛋白修饰之一。其中H3K36me3的研究较多,主要在基因区富集,功能包括调控转录起始[1],pre-mRNA的剪切,异常转录的抑制,RNA m6A修饰和DNA修复等。而H3K36me2目前研究较少,在基因区和基因间区都有富集,通常与其他组蛋白修饰协同调控基因的表达。之前的研究发现NSD1介导的H3K36me2可以抑制全基因组内H3K27me3的扩增[2],从而间接...
Repetition can be useful if you're trying to memorize a poem, master a guitar riff, or just cultivate good habits. When this kind of behavior becomes compulsive, however, it can get in the way of norm...
2018年9月12日,王立铭实验室在Cell Research在线发表题为"A post-ingestive amino acid sensor that promotes food consumption in Drosophila" 的研究论文,发现了果蝇中枢神经系统检测食物中氨基酸和据此调控进食行为的机制。无论是聚合成多肽、蛋白,还是以单体形式存在,氨基酸在生物体内发挥着诸多重要的功能。哺乳...
How different are human brains compared to the brains of other primates such as chimpanzees, gorillas and monkeys? It’s one of many important questions that scientists have asked for years while pursu...
2017年11月23日,南方科技大学生物系副教授姬生健课题组在著名国际期刊《Nucleic Acids Research》(《核酸研究》)在线发表了题为“Dynamic m6A modification regulates local translation of mRNA in axons”的研究论文。这一研究揭示了m6A修饰通过调控信使核糖核酸(mRNA)在神经元轴突中的局部翻译进而影响轴突生...
The National Science Foundation (NSF) has made 17 Next Generation Networks for Neuroscience (NeuroNex) awards to aid the research community as it pursues one of its grandest challenges: understanding ...
A National Science Foundation (NSF) program recently awarded 17 projects a total of $51 million to develop and implement bold, new, potentially transformative models for graduate education in science,...
The Gordon Research Seminar on Neuroethology: Behavior, Evolution and Neurobiology is a unique forum for graduate students and post-docs to present their work, exchange experiences, and discuss cuttin...
The 2017 Gordon Research Conference on Neuroethology will focus on "Neural, Behavioral and Evolutionary Strategies for Animal Survival". The core focus of Neuroethology is the understanding of the neu...
This is the inaugural GRC on the Neurobiology of Drug Addiction, which will include investigators from a wide range of countries to discuss the latest developments in addiction research in an open and...
There is likely no greater hot-button topic in biomedical and clinical research today than discussions surrounding the utility of active chemicals found in marijuana and how they interact within the b...
Almost all brain disorders are associated with cognitive impairment. For many clinicians and neuroscientists, cognitive dysfunction is specific for dementia. It is not until recently that the research...

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