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中国科学院昆明动物研究所揭示泛素连接酶HECTD3调控病原菌感染诱导IFN-I产生的机制（图）
中国科学院昆明动物研究所 泛素连接酶 HECTD3 病原菌感染 IFN-I 产生机制
2018/6/26
HECTD3是属于HECT家族的一个E3泛素连接酶，目前对该蛋白的研究很少。中国科学院昆明动物研究所研究员陈策实前期的研究证实，HECTD3在乳腺癌、前列腺癌中高表达，促进肿瘤细胞对化疗药物的抗性，增加了肿瘤细胞的存活（Li et al. Cell Death Dis, 2013; Li et al. Neoplasia, 2013）；并建立了Hectd3基因敲除小鼠模型。在此基础上，陈策实与昆明...
Effects of IFN-γ on IL-18 Expression in Pregnant Rats and Pregnancy Outcomes
Interleukin-18 Interferon-γ Pregnant Rat Immunohistochemistry Uterus Abortion
2016/5/12
The present study focused on establishing the effects of interferon-gamma (IFN-γ) on interleukin-18 (IL-18) expression patterns and pregnancy outcomes in pregnant rats. Pregnant rats at the post-impla...
Tissues Expression, Polymorphisms of IFN Regulatory Factor 6 (IRF6) Gene and Their Associated with Immune Traits in Three Pig Populations
Pig, IRF6, Expression, Polymorphisms, Association Analysis
2016/5/9
Interferon regulatory factor 6 (IRF6) gene is a member of the IRF-family, and plays functionally diverse roles in the regulation of the immune system. In this report, the 13,720 bp porcine IRF6 genomi...