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Stroke杂志:CNSR-III研究发现脂蛋白(a)对卒中复发的影响在低LDL-C(低密度脂蛋白)和炎症水平时减弱(图)
国家神经系统疾病临床医学研究中心 低密度脂蛋白 胆固醇 动脉粥样硬化
2022/9/9
2022年4月12日国际脑血管病权威杂志《Stroke》杂志全文发表了由首都医科大学附属北京天坛医院、国家神经系统疾病临床医学研究中心—脂代谢与动脉粥样硬化中心王拥军教授团队的研究文章“Effect of Lipoprotein(a) on Stroke Recurrence Attenuates at Low LDL-C (Low-Density Lipoprotein) and Inflamm...
分析脑梗死患者血清氧化低密度脂蛋白(oxidized low density lipoprotein,ox-LDL)、白细胞介素-18(IL-18)以及脂蛋白相关磷酯酶 A2(lipoprotein-associated phosphatase A2,Lp-PLA2)水平与颈动脉硬化斑块的相关性。方法:选取2018年3月至2019年3月本院收治的120例脑梗死患者(研究组)和同期35例健康志愿者(...
观察三七化瘀丸对不稳定型心绞痛(UAP)病人血清超敏-C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、低密度脂蛋白胆固醇(LDL-C)及颈动脉斑块的影响。方法采用随机方法将佛山市中医院心病科2015年3月—2016年5月收治的UAP病人103例分为对照组和观察组。对照组采用西医常规药物治疗,观察组在对照组基础上联合三七化瘀丸口服,观察并比较两组临床疗效、血清hs-CRP、IL-6、LDL-...
观察栀子苷对ox-LDL诱导的RAW264.7来源泡沫细胞DNA甲基化的作用。方法以ox-LDL诱导RAW264.7细胞形成泡沫细胞模型;CCK-8法检测不同浓度栀子苷对泡沫细胞的增殖抑制情况;将细胞分为4组,分别为空白对照组(无处理)、模型组(80 μg/mL ox-LDL处理)、栀子苷小剂量组 (80 μg/mL ox-LDL +30 μg/mL栀子苷)、栀子苷大剂量组(80 μg/mL ox...
观察大脑中动脉穿支供血区单发脑梗死依据CISS分型情况,及LDL-C、超敏-C反应蛋白水平与不同分型间的关系。方法 连续入选100例急性大脑中动脉穿支供血区单发脑梗死患者,依据CISS分型进行二次分型,同时测定LDL-C、超敏-C反应蛋白水平,比较不同分型组间的LDL-C、超敏-C反应蛋白水平。
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首都医科大学附属北京天坛医院王伊龙教授团队《Neurology》揭示氧化LDL可预测轻型卒中及TIA复发(图)
首都医科大学附属北京天坛医院 王伊龙 教授 Neurology 氧化LDL 可预测 轻型卒中 TIA复发
2019/1/16
2018年9月,首都医科大学附属北京天坛医院王伊龙教授团队在《Neurology》(IF:8.515)发表题为" Oxidized Low-density Lipoprotein Predicts Recurrent Stroke in Patients with Minor Stroke or TIA "的论文。研究团队通过探索氧化低密度脂蛋白(oxLDL)与轻型卒中和短暂性脑缺血发作(TIA)...
Cashew consumption reduces total and LDL cholesterol: a randomized, crossover, controlled-feeding trial
cardiovascular cashew cholesterol clinical trial hypercholesterolemia
2018/11/13
Background: Cashews are the third most-consumed tree nut in the United States and are abundant with monounsaturated fatty acids and polyunsaturated fatty acids, which are associated with reduced cardi...
基于自噬小体形成信号通路探讨丹参酮ⅡA对ox-LDL诱导内皮细胞氧化应激损伤的保护作用及机制。 方法 体外培养EA. hy926细胞,随机分为正常组、模型组、丹参酮ⅡA组、丹参酮ⅡA+模型组、3-MA组、模型+3-MA组、丹参酮ⅡA+模型+3-MA组。比色法检测各组细胞氧化应激损伤丙二醛(MDA)含量及超氧化物歧化酶(SOD)活力,Western blot技术检测细胞自噬小体形成信号通路相关蛋白表...
黄芩苷对ox-LDL诱导的人脐静脉内皮细胞损伤的保护作用
动脉粥样硬化 氧化型低密度脂蛋白 黄芩苷 人脐静脉内皮细胞
2018/9/20
观察黄芩苷对氧化型低密度脂蛋白(ox-LDL)诱导的血管内皮细胞的保护作用。 方法 将体外培养的人脐静脉内皮细胞(EAhy926)分成对照组、ox-LDL组、黄芩苷组和不同浓度的黄芩苷(25、50和100 mg/L)+ox-LDL组,培养24 h。采用CCK-8检测细胞活力,ELISA检测细胞培养上清液中TNF-α和IL-6水平,Western blot检测凋亡相关蛋白Bax和Bcl-2的表达。 ...
应用小鼠高脂模型及树突状细胞株研究血凝素样氧化型低密度脂蛋白受体1(LOX-1)高表达树突状细胞(DC)在动脉粥样硬化中的作用。方法 氧化型低密度脂蛋白(ox-LDL)诱导原代培养的C57小鼠骨髓来源的树突状细胞(BMDC),采用Western blot检测BMDC LOX-1蛋白水平;采用流式细胞术检测高表达LOX-1和低表达LOX-1细胞亚群的比例;MACS磁珠分选LOX-1表达水平不同的两种...
Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans
Cocoa powder dark chocolate LDL oxidation
2016/6/14
Flavonoids are polyphenolic compounds of plant
origin with antioxidant effects. Flavonoids inhibit LDL oxidation
and reduce thrombotic tendency in vitro. Little is known about
how cocoa powder and ...
Pork with a high content of polyunsaturated fatty acids lowers LDL cholesterol in women
Designed foods pork fatty acids
2016/6/14
Animal products contribute significantly to the saturated
fat and cholesterol content of the American diet. Contrary
to dietary advice, consumers have not limited their consumption
of animal produc...
Consumption of flavonoids in onions and black tea: lack of effect on F2-isoprostanes and autoantibodies to oxidized LDL in healthy humans
Flavonoid onions black tea antioxidant
2016/6/13
Oxidative damage to lipids in vivo may be
involved in the development of atherosclerosis and cancer.
Onions and black tea are foods rich in flavonoids, predominantly
the flavonoid quercetin, which ...
Alcohol drinking determines the effect of the APOE locus on LDL-cholesterol concentrations in men: the Framingham Offspring Study
Apolipoprotein E genetics lipoproteins
2016/6/13
The effect of alcohol drinking on LDL-cholesterol
concentrations is unclear. The reported variability may be due to
interactions between genetic factors and alcohol intake.
Zock and Katan (1) gave a good analysis in their recent editorial
of the diet–LDL oxidation–coronary artery disease hypothesis.
We would like to expand on the theoretical pathways involved
in the o...