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Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome
homocysteine metabolism gene polymorphisms
2016/6/1
One of the major advances in preventing malformations in the
past few decades had its origin in the observation by Smithells et
al (1) that multivitamin preparations are protective against neural
t...
The Association between Sporadic Alzheimer’s Disease and the Human ABCA1 and APOE Gene Polymorphisms in Iranian Population
Alzheimer’s disease Genetic association Apolipoprotein E Polymorphism ATP-binding cassette transporter A1 Iran
2015/9/23
Background: Apolipoprotein E (APOE), which its ε4 allele has been reported as a risk factor in late onset Alzheimer’s disease (AD), is the main cholesterol carrier in the brain. ATP-binding cassette t...
Interleukin-12 and Tumor Necrosis Factor-Β Gene Polymorphisms as Genetic Susceptibility Factors for Brucellosis in Iranian Patients
Brucella Genetic polymorphisms Interleukin-12 Tumor necrosis factor-β Iran
2015/9/21
cMethods: One hundred and ninety-six patients with brucellosis and 81 healthy farmers (controls) who owned infected animals and consumed their contaminated dairy products were included in this study. ...
Heme Oxigenase 2 Gene Polymorphisms as Genetic Risk Factor in Atherosclerosis in Iranian Patients
Atherosclerosis Heme oxigenase 2 Coronary artery disease Iran
2015/9/21
Background: Heme oxygenase 2 (HMOX2) is an important antioxidative stress enzyme found in the endothelial cells of blood vessels and adventitial nerves. This enzyme in collaboration with heme oxygenas...
N-acetyltransferase 2 gene polymorphisms and susceptibility to prostate cancer: a pilot study in the Turkish population
N-Acetyltransferase 2 prostate cancer acetylator phenotype
2010/10/14
To investigate the association between the 3 most frequently observed single nucleotide polymorphisms of the NAT2 gene and the risk of developing prostate cancer in the Turkish population. Materials a...
Association between Endothelial Selectin (E-Selectin) Gene Polymorphisms and E-Selectin Level with Visceral Leishmaniais, in an ARMS-PCR Based Study
Soluble E-selectin Gene Polymorphism Visceral Leishmaniasis Human ARMS-PCR Ser128Arg 554Leu/Phe
2009/12/18
Background: In the visceral leishmaniasis (VL), parasites reside in reticuluendothelial system, mainly in macrophages. Endothelial Selectin (E-selectin) might play an important role in leukocyte-endot...
Gene Polymorphisms and Chemotherapy in Non-small Cell Lung Cancer
Lung neoplasms Genetic polymorphism Drug therapy
2013/12/10
The phamacogenetics is being used to predict whether the selected chemotherapy will be really effective and tolerable to the patient. Irinotecan, oxidized by CYP3A4 to produce inactive compounds, is u...
Ameloblastin gene polymorphisms in healthy Japanese
Ameloblastin Amelogenesis imperfecta Gene polymorphisms Japanese
2008/4/19
Ameloblastin is one of the extracellular matrix proteins in tooth enamel and may be responsible for autosomal amelogenesis imperfecta (AI), since it plays a significant role in enamel crystal growth. ...
Apolipoprotein B gene polymorphisms and serum lipids: meta-analysis of the role of genetic variation in responsiveness to diet
Apolipoprotein B cholesterol diet meta-analysis, human polymorphism restriction endonuclease restrictionfragment-length polymorphism restriction-site polymorphism, plasma lipids
2016/6/3
Background: The genetic variance determining plasma lipid and
lipoprotein concentrations may modify individual responsiveness
to alterations in dietary fat and cholesterol content.
Objective: The a...