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Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level
Cholecalciferol calcidiol vitamin D3
2016/6/12
The Food and Nutrition Board of the National
Academy of Sciences states that 95 g vitamin D/d is the lowest
observed adverse effect level (LOAEL).
Vitamin D activity of breast milk in women randomly assigned to vitamin D3 supplementation during pregnancy,
breast milk vitamin D 25-hydroxyvitamin D pregnancy supplementation infant feeding
2018/11/27
Background: Human milk is typically low in vitamin D activity (VDA). Whether the vitamin D content of breast milk at birth can be increased by supplementing the mother during pregnancy has not been re...
Chemoprevention of MNU and Testosterone induced prostate carcinogenesis by Calcitriol (vitamin D3) in adult male albino Wistar rats
Calcitriol Chemoprevention Methyl nitroso urea Prostate cancer Prostatic intraepithelial neoplasia
2009/7/15
Background Calcitriol is a steroid hormone, inhibits the proliferation and promotes the differentiation of human prostate cancer cells. Calcitriol markedly inhibits the invasiveness of human prostate ...
The skeletal benefits of calcium- and vitamin D3–fortified milk are sustained in older men after withdrawal of supplementation: an 18-mo follow-up study1,2,3
Milk supplementation fortified milk supplement withdrawal men bone mineral density
2009/4/20
Background: In a previous 2-y randomized controlled trial, we showed that calcium- and vitamin D3–fortified milk stopped or slowed bone loss at several clinically relevant skeletal sites in older me...
Immunomodulating effect of vitamin D3 derivatives on type-1 cellular immunity
vitamin D3 type-1 cellular immunity
2009/3/2
1α,25-dihydroxyvitamin D3 [Calcitriol or 1,25(OH)2D3] is an important active metabolite involved in multiple functions but its calcemic effect in vivo limits its therapeutic applications. On the oth...
Safety of vitamin D3 in adults with multiple sclerosis
Vitamin D safety 25-hydroxyvitamin D 25(OH)D multiple sclerosis
2008/12/17
Background: Vitamin D3 may have therapeutic potential in several diseases, including multiple sclerosis. High doses of vitamin D3 may be required for therapeutic efficacy, and yet tolerability—in the ...
Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients
biochemical responses vitamin D3
2008/4/23
For adults, vitamin D intake of 100 mcg (4000 IU)/day is physiologic and safe. The adequate intake (AI) for older adults is 15 mcg (600 IU)/day, but there has been no report focusing on use of this do...
Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity
anthropometry vitamin D3
2008/4/23
Low serum 25 hydroxyvitamin D3 (vitamin D3) is known to perturb cellular function in many tissues, including the endocrine pancreas, which are involved in obesity and type II diabetes mellitus (TIIDM)...
PROTECTIVE EFFECT OF VITAMIN D3 IN METHYLPREDNISOLONE ACETATE (MPA) INDUCED LOSS OF BONE METABOLISM MARKERS AND BONE MINERAL DENSITY IN THE LUMBAR SPINE OF RAT
Methylprednisolone acetate vitamin D3 bone markers metabolism
2010/4/7
Although some vitamins have been shown to prevent glucocorticoids induced osteoporosis in short time, the magnitude of this effect remains to be clarified. The aim of this study was to evaluate protec...
25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions
Vitamin D vitamin D3
2016/12/30
Neither the efficiency of the 25-hydroxylation of vitamin D nor the steady state relation between vitamin D3 and 25-hydroxyvitamin D [25(OH)D] has been studied in humans.