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Nanoscale Changes in Collagen are Reflected in Physical and Mechanical Properties of Bone at the Microscale in Diabetic Rats
Zucker diabetic Sprague–Dawley Atomic Force Microscopy Raman Spectroscopy
2014/12/4
Diabetes detrimentally affects the musculoskeletal system by stiffening the collagen matrix due to increased advanced glycation end products (AGEs). In this study, tibiae and tendon from Zucker diabet...
Effects of kirenol on bovine type II collagen-induced rat lymphocytes in vivo and in vitro
奇壬醇 II型胶原 淋巴细胞 类风湿性关节炎
2012/4/24
目的观察奇壬醇对牛II 型胶原特异性淋巴细胞体内和体外的免疫调节作用，探讨奇壬醇对抗原特异性淋巴细胞的免疫抑制作用机制。方法将Wistar 大鼠随机分为对照组、模型组、奇壬醇组和泼尼松龙组。除对照组外，均复制胶原诱导关节炎大鼠模型，造模当天开始给药。造模30 d 后取脾脏和引流淋巴结，制备单细胞悬液，经体外培养48 h 后，ELISA法检测培养上清中干扰素-γ（IFN-γ）、白介素-10（IL-1...
Effect of Tindurin on Immunopathogenesis Mechanism of Collagen-Induced Arthritis
Anti-malarial drugs Tindurin
2009/12/30
Rheumatoid arthritis is a chronic inflammatory disease characterized by the sequestration of various leukocyte subpopulations within both the developing pannus and synovial space. This study was under...
Adhesion rates and chondrocyte phenotype in monolayer cultures under the influence of Collagen type II and IGF-I
Chondrocyte phenotype Collagen type II IGF-I Integrin Immunoelectron microscopy
2009/12/25
When grown in monolayer culture at low density and with the addition of serum, cartilage cells dedifferentiate or are overgrown by fibroblast-like cells. The aim of this study was to optimize the cult...
Quantification of Total Collagen in Rabbit Tendon by the Sirius Red Method
Collagen sirius red hydroxyproline tendon
2009/7/2
Collagen, as a fibrous protein constituting approximately one third of the total protein in the body is synthesized by fibroblasts and is a major component of extracellular matrix in many tissues such...
The Type and Frequency of Infections Occurring in Collagen Tissue Diseases
Collagen tissue diseases Infection Corticosteroid Cytotoxic drugs
2009/6/29
Corticosteroids, widely used in the treatment of collagen tissue diseases, increase the number of neutrophils and decrease the total numbers of lymphocytes, monocytes, eosinophils and basophils. In ad...