搜索结果: 1-15 共查到“医学细胞生物学 bone”相关记录29条 . 查询时间(0.159 秒)
骨质疏松症一种以骨量低下、骨组织微结构损坏，导致骨脆性增加，易发生骨折为特征的全身性骨病。大量研究证实，细胞外囊泡（EVs）在调控骨稳态的复杂机制中发挥重要的作用，这些囊泡在病理和生理环境中都起着至关重要的作用，而不同来源的EVs对骨质疏松症有明显且不同的影响。
Study:Changing the environment within bone marrow alters blood cell development
Changing the environment bone marrow blood cell development
2017/3/14
Researchers at the University of Illinois report they can alter blood cell development through the use of biomaterials designed to mimic characteristics of the bone marrow.The findings, reported in th...
Bone material properties and mineral matrix contributions to fracture risk or age in women and men
collagen osteoporosis
2014/12/4
The strength of bone is related to its mass and geometry, but also to the physical properties of the tissue itself. Bone tissue is composed primarily of collagen and mineral, each of which changes wit...
Introduction – Bone turnover and fracture risk
osteoporosis bone turnover fracture remodeling
2014/12/4
Introduction – Bone turnover and fracture risk.
Osteoporosis and fracture risk: bone matrix quality
remodeling bisphosphonates mineralization
2014/12/4
Osteoporosis and fracture risk: bone matrix quality.
Identification of material parameters based on Mohr-Coulomb failure criterion for bisphosphonate treated canine vertebral cancellous bone
material parameter identification Mohr-Coulomb failure criterion trabecular bone
2014/12/4
Nanoindentation has been widely used to study bone tissue mechanical properties. The common method and equations for analyzing nanoindentation, developed by Oliver and Pharr, are based on the assumpti...
Parathyroid Hormone Enhances Mechanically Induced Bone Formation, Possibly Involving L-Type Voltage- Sensitive Calcium Channels
parathyroid hormone bone formation
2014/12/4
PTH and mechanical loading might act synergistically on bone formation. We tested the in vivo effect of the L-type voltage-sensitive calcium channel (VSCC) blocker, verapamil, on bone formation induce...
Exercise-Induced Changes in the Cortical Bone of Growing Mice Are Bone and Gender Specific
mechanical properties pQCT matrix changes
2014/12/4
Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to no...
Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body
trabecular bone cortical shell suppressed bone turnover
2014/12/4
The relative biomechanical effects of antiresorptive treatment on cortical thickness vs. trabecular bone microarchitecture in the spine are not well understood. To address this, T-10 vertebral bodies ...
Alendronate treatment results in similar levels of trabecular bone remodeling in the femoral neck and vertebra
anti-remodeling bisphosphonates animal models
2014/12/4
Introduction Bone turnover suppression in sites that already have a low surface-based remodeling rate may lead to oversuppression that could have negative effects on the biomechanical properties of bo...
A computational assessment of the independent contribution of changes in canine trabecular bone volume fraction and microarchitecture to increased bone strength with suppression of bone turnover
trabecular bone bone strength suppressed bone turnover
2014/12/4
This study addressed the effects of changes in trabecular microarchitecture induced by suppressed bone turnover—including changes to the remodeling space—on the trabecular bone strength–volume fractio...
Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following three years of daily treatment
Bisphosphonates remodeling suppression
2014/12/4
Reduced bone toughness, the energy absorption capacity of the tissue, has been consistently documented in vertebrae of animals treated with a wide range of bisphosphonate doses. Data regarding toughne...
Bone quality: Understanding what matters.
High Bone Mass in Mice Lacking Cx37 Due to Defective Osteoclast Differentiation
gap junctions connexin37 osteoclast
2014/12/4
Connexin (Cx) proteins are essential for cell differentiation, function and survival in all tissues with Cx43 being the most studied in bone. We now report that Cx37, another member of the connexin fa...
Short-courses of dexamethasone abolish bisphosphonate-induced reductions in bone toughness
zoledronic acid mechanical properties toughness remodeling suppression
2014/12/4
Atypical femoral fractures, which display characteristics of brittle material failure, have been associated with potent remodeling suppression drugs. Given the millions of individuals treated with thi...