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Cholesterol-metabolism study suggests new diagnostic, treatment approach for aggressive prostate cancer（图）
diagnostic prostate cancer
2014/3/20
WEST LAFAYETTE, Ind. - Researchers have discovered a link between prostate cancer aggressiveness and the accumulation of a compound produced when cholesterol is metabolized in cells, findings that cou...
Androgen regulation of the human ornithine decarboxylase promoter in prostate cancer cells
Androgen receptor gene regulation
2009/2/17
We studied the response of the human ornithine decarboxylase (ODC) promoter to androgen in human prostate cancer cell lines. In the well-differentiated, androgen-sensitive human prostate cancer li...
Serum androgens：associations with prostate cancer risk and hair patterning
Prostatic neoplasms hormones testosterone baldness
2009/2/17
Cancer of the prostate is the leading cancer among American men, yet few risk factors have been established. Hair growth and development are influenced by androgens, and it has long been suspected...
Androgen receptor regulation of G1 cyclin and cyclin-dependent kinase function in the CWR22 human prostate cancer xenograft
Androgen receptor regulation G1 cyclin cyclin-dependent kinase CWR22 huma prostate cancer
2008/12/29
Human prostate cancer is initially dependent on androgens for growth, and androgen-dependent cells undergo apoptosis after castration. However, a subset of androgen-responsive cells survives and event...
Differential expression of CCAAT/enhancer-binding protein-delta（c/EBPdelta）in rat androgen-dependent tissues and human prostate cancer
CCAAT/enhancer-binding protein-delta（c/EBPdelta） rat androgen-dependent tissues human prostate cancer
2008/12/26
CCAAT/enhancer-binding protein delta (C/EBPdelta) is a nuclear transcription factor that regulates cellular growth and differentiation. In this study we demonstrate that C/EBPdelta gene expression i...
Biphasic Effect of Androgens on Prostate Cancer Cells and Its Correlation With Androgen Receptor Coactivator Dopa Decarboxylase
Neuroendocrine differentiation methyltoenolone cDNA microarray
2008/12/24
The aim of this study was to explore the mechanism underlying the dual effect of androgen on prostate cancer cells and further explore its correlation with dopa decarboxylase (DDC), an androgen r...
Metastatic Prostate Cancer After Orchiectomy, Radiotherapy, and Testosterone Replacement in a Patient With Bilateral Seminoma
Metastatic Prostate Cancer Orchiectomy Radiotherapy Testosterone Replacement Bilateral Seminoma
2008/12/24
Although its clinical benefits remain unproven and its indications controversial, the popularity of testosterone replacement therapy has grown substantially in recent years, in order to maintain v...
Circulating Inflammatory Cytokine Expression in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy
Hypogonadism inflammation
2008/12/24
Prostate cancer (PCa) is one of the most common cancers in men. Androgen deprivation therapy (ADT) is employed in the treatment of patients with metastatic or recurrent PCa, resulting in castrate le...
Androgens Induce Increases in Intracellular Calcium Via a G Protein–Coupled Receptor in LNCaP Prostate Cancer Cells
5-Dihydrostestosterone Ca2+ GPCR
2008/12/24
The receptor mechanism of testosterone-induced nongenomic Ca2+ signaling in prostate cancer cells is poorly understood. In this study we investigated androgen-induced intracellular Ca2+ increa...
Gene Expression in Prostate Cancer Cells Treated With the Dual 5 Alpha-Reductase Inhibitor Dutasteride
LNCaP gene-expression profiling REDUCE trial apoptosis
2008/12/22
We sought preclinical data on the cellular and molecular effects of dutasteride in androgen-responsive, human prostate cancer (PCa) cells to better understand the mechanisms of action of 5 alpha-red...
Autologous Tunica Vaginalis and Subcapsular Orchiectomy：A Hormonal Therapy for Prostate Cancer
Castration body image
2008/12/22
Two novel surgical procedures that combine an autologous tunica vaginalis pedicle graft (TVG) with a subcapsular orchiectomy (SCOT) were evaluated in asymptomatic patients with rising prostate-speci...
Medical Castration With LHRH Agonists：25 Years Later With Major Benefits Achieved on Survival in Prostate Cancer
Medical Castration With LHRH Agonists Major Benefits Achieved Survival Prostate Cancer
2008/12/22
Prostate cancer is the most frequently diagnosed cancer and the second cause of cancer death in men in North America (Jemal et al, 2003). In fact, one of eight men will be diagnosed with prostate canc...
Molecular Analysis of the Androgen Receptor in Ten Prostate Cancer Specimens Obtained Before and After Androgen Ablation
Androgen ablation androgen receptor CAG repeat mutations prostate cancer
2008/12/19
Hormonal or androgen-ablation (AA) therapy is the predominant form of systemic treatment for metastatic prostate cancer. Although an initial response to AA is observed in 70%–80% of patients with ad...
The original hypothesis of Schwartz and Hulka (1990) proposing that vitamin D deficiency may be a risk factor for prostate cancer has triggered many studies. Epidemiological studies have supported t...