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Kinetic characterization of the inhibition of purified cynomolgus monkey lactate dehydrogenase isozymes by gossypol
Kinetic characterization purified cynomolgus monkey dehydrogenase isozymes gossypol
2009/2/23
This report describes the results of the first step in a sequence of experiments designed to test the hypothesis that the sperm-specific isozyme of lactate dehydrogenase (LDH-C4), is a site of actio...
Estradiol and high-dose dihydrotestosterone treatment causes changes in cynomolgus monkey prostate volume and histology identical to those caused by testosterone alone
Male transrectal ultrasonography androgens estrogens
2009/2/18
To evaluate the effects of testosterone (T), dihydrotestosterone (DHT), and estradiol (E2) on the regulation of prostate growth and tissue composition, the following study was conducted in a nonhuma...
Effect of acute androgen withdrawal by GnRH antagonist on epididymal sperm motility and morphology in the cynomolgus monkey
acute androgen withdrawal GnRH epididymal sperm motility
2009/2/18
Hormonal male contraception requires an induction phase before azoospermia and contraceptive safety are achieved. The nature of spermatozoa that may be ejaculated during this induction phase was s...
Pharmacokinetics of 7 alpha-methyl-19-nortestosterone in men and cynomolgus monkeys
MCR SHBG replacement therapy male
2009/2/17
Testosterone and its esters are widely used for androgen replacement therapy. In the prostate, testosterone ins 5 alpha-reduced to dihydrotestosterone (DHT), which leads to an amplification of its...
Sperm-zona pellucida interaction in cynomolgus and rhesus macaques
Sperm-zona pellucida interaction cynomolgus rhesus macaques
2009/2/11
These experiments were carried out to establish and validate an in vitro system for studying macaque sperm-zona pellucida interaction. Sperm of rhesus and cynomolgus macaques were capacitated in vit...
Calpain and calpastatin are located between the plasma membrane and outer acrosomal membrane of cynomolgus macaque spermatozoa
Calpain calpastatin plasma membrane outer acrosomal membrane cynomolgus macaque spermatozoa
2008/12/25
Mammalian sperm must undergo an acrosome reaction prior to penetration of the zona pellucida and subsequent fusion with an oocyte. Sperm gain the capability to acrosome react after a period of capac...
Progesterone-induced calcium influx in cynomolgus monkey（Macaca fascicularis）spermatozoa
Progesterone-induced calcium cynomolgus monkey spermatozoa
2008/12/25
For in vitro capacitation to occur in cynomolgus monkey (Macaca fascicularis) spermatozoa, there is an absolute requirement for exogenous stimulation with the sperm activators, caffeine (1 mM) and d...
Expression of Orphan Receptors TR2, TR3, TR4, and p53 in Heat-Treated Testis of Cynomolgus Monkeys（Macaca fascicularis）
Heat shock spermatogenesis primate
2008/12/24
To investigate the possible role of testicular orphan receptors (TR) TR2, TR3, and TR4 in the process of germ cell apoptosis in the heat-treated testis of monkey, we have examined the spatiotemporal...
Effects of Various Extenders and Permeating Cryoprotectants on Cryopreservation of Cynomolgus Monkey（Macaca fascicularis）Spermatozoa
Sperm freezing motility plasma membrane acrosome permeability coefficient
2008/12/23
The cryoprotective effects of 11 different extenders, TTE, DM, mDM, LG-DM, G-DM, TCG, TEST, TSM, Test-M, Test-H, and LM, on sperm cryopreservation of cynomolgus monkey (Macaca fascicularis) have bee...
Mild Testicular Hyperthermia Induces Profound Transitional Spermatogenic Suppression Through Increased Germ Cell Apoptosis in Adult Cynomolgus Monkeys (Macaca fascicularis)(
Azoospermia germ cell death heat primate spermatogenesis
2008/12/15
We have previously demonstrated that mild testicular hyperthermia induces stage-specific and germ cell—specific apoptosis in rat and mouse testes. The objectives of this pilot study were to examine wh...