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Modulation of insulin-like growth factor-1 in the seminal plasma of infertile men
Modulation insulin-like growth factor-1 seminal plasma infertile men
2009/2/18
It has been suggested that insulin-like growth factor (IGF)-1 plays an important role in the regulation of spermatogenesis in the testes. In the present study, concentrations of total IGF-1 we...
Levels of hepatocyte growth factor/scatter factor（HGF/SF）in seminal plasma of patients with andrological diseases
Testis spermatozoa male infertility
2009/2/17
Hepatocyte growth factor/scatter factor (HGF/SF) has all the characteristics of a molecule suitable for functioning in regulatory networks of motility, such as the spermatogenic epithelium, where sper...
Transforming growth factor-beta1（TGF-beta1）in penile and prostate growth in the rat during sexual maturation
Penis androgen receptors
2009/2/17
The goal of this study was to determine whether transforming growth factor-beta1 (TGF-beta1) may contribute to the arrest of penile growth and the down-regulation of androgen receptors (AR) that occ...
An orthotopic model for the study of growth factors in the ventral prostate of the rat：effects of epidermal growth factor and basic fibroblast growth factor
growth factors ventral prostate rat epidermal growth factor basic fibroblast growth factor
2009/2/12
In order to determine if epidermal growth factor (EGF) or basic fibroblast growth factor (bFGF) are capable of stimulating prostatic growth in situ, we complexed EGF and bFGF to a Matrigel (MG) ve...
Effects of epidermal growth factor on human sperm cell function
epidermal growth factor human sperm cell function
2009/2/12
The effects of human recombinant epidermal growth factor (EGF) on the fertilizing capacity of human sperm were investigated. At lower concentrations (0.1-10 nM) EGF did not significantly (P > 0.05...
Immunohistochemical localization of insulin-like growth factor I（IGF-I）in the rat epididymis
Immunohistochemical localization insulin-like growth factor I（IGF-I） rat epididymis
2009/2/12
The distribution of insulin-like growth factor I (IGF-I) was studied by immunohistochemistry during postnatal development of the rat epididymis. At 2 weeks the immunoreactivity was mainly located al...
Sertoli cell secreted growth factor. Cellular origin, paracrine and endocrine regulation of secretion
Sertoli cell Cellular origin paracrine endocrine regulation secretion
2009/2/12
Rat and human Sertoli cells in culture secrete a growth factor, Sertoli cell secreted growth factor (SCSGF). The aims of the present study were (1) to evaluate other testicular cell types as additio...
Insulin-like growth factor 1, but not growth hormone, has in vitro proliferative effects on neonatal foreskin fibroblasts without affecting 5-alpha-reductase or androgen receptor activity
5-a-Reductase androgen receptor micropenis
2009/2/11
Clinical observation of patients with congenital growth hormone (GH) deficiency and Laron-type dwarfism suggests that factors such as GH or insulin-like growth factor 1 (IGF-1) might in addition to ...
Role of nerve growth factor-like protein in the paracrine regulation of prostate growth
protein paracrine regulation prostate growth
2009/2/11
Prostate cancer is the most commonly diagnosed form of malignant neoplasia in men. Considerable evidence has accumulated suggesting that paracrine interactions between stromal cells and epithelial cel...
Effects of insulin-like growth factor-I on androgen production by highly purified pubertal and adult rat Leydig cells
Somatomedin-C development steroidogenesis
2009/2/10
Leydig cells were isolated and purified from adult and midpubertal rats to study the effects of insulin-like growth factor-I (IGF-I) on steroidogenesis. Androgen production, as measured in Leydig ce...
Expression, action, and regulation of transforming growth factor alpha and epidermal growth factor receptor during embryonic and perinatal rat testis development
FSH gametogenesis mesenchymal-epithelial Sertoli
2008/12/29
The objective of the current study was to extend previous observations and examine the expression pattern and effects of transforming growth factor alpha (TGFalpha) and epidermal growth factor recep...
Epidermal growth factor modulates the expression of vascular endothelial growth factor in the human prostate
Epidermal growth factor vascular endothelial growth factor human prostate
2008/12/26
The growth and dissemination of tumors in the body has been associated with angiogenesis. Vascular endothelial growth factor (VEGF) is an angiogenic factor that stimulates endothelial cell growth and ...
Effects of luteinizing hormone, follicle-stimulating hormone, and epidermal growth factor on expression and kinase activity of cyclin-dependent kinase 5 in Leydig TM3 and Sertoli TM4 cell lines
luteinizing hormone follicle-stimulating hormone growth factor kinase activity cyclin-dependent kinase 5
2008/12/25
We examined the effects of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and epidermal growth factor (EGF) on the expression and kinase activity of cyclin-dependent kinase 5 (Cdk5)...
Hepatocyte Growth Factor-Modulated Rat Leydig Cell Functions
c-met HGF testosterone caspase-3 apoptosis testis
2008/12/24
Hepatocyte growth factor (HGF) regulates many cellular functions acting through c-Met, its specific tyrosine kinase receptor. We previously reported that in prepuberal rats HGF is secreted by the pe...
Functional Role of Hepatocyte Growth Factor Receptor During Sperm Maturation
C-met spermatozoa rat testis epididymis
2008/12/16
Mammalian spermatozoa acquire motility and fertilizing capacity during their transit through the epididymis. Hepatocyte growth factor (HGF) is a pleiotropic cytokine with potent motogenic capacities t...