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A 53-year-old man with chronic myeloid leukaemia developed significant hepatic dysfunction when treatment was changed from imatinib (because of drug-induced rash) to dasatinib. Liver function tests re...
Overexpression of MyoD Attenuates Denervated Rat Skeletal Muscle Atrophy and Dysfunction
MyoD Denervation Rat Skeletal Muscle Atrophy Dysfunction
2013/1/30
Nerve injury commonly contributes to irreversible functional impairment, reconstruction of the function of muscle is big challenge. In denervated skeletal muscle, therapid expression of MyoD mRNA and ...
Pituitary-Thyroid Dysfunction in a Hashimoto’s Encephalopathy Patient
Hashimoto’s Thyroiditis Hashimoto’s Encephalopathy Pathogenesis Hypothyroidism Pituitary Gland
2013/1/30
The pathogenesis of Hashimoto’s encephalopathy has not been clearly elucidated and involvement of autoimmune damage has been proposed. We report a 23-year-old man who was emergently hospitalized for p...
Type 2a sodium-phosphate co-transporter serves as a histological predictor of renal dysfunction and tubular apical damage in the kidneys of septic mice
renal dysfunction tubular apical damage
2009/12/16
Acute renal failure (ARF) occurs in septic patients and is histologically characterized by tubular apical damages, including brush border breakdown. Nevertheless, little information is available to id...
N-hexacosanol prevents diabetes-induced rat ileal dysfunction without qualitative alteration of the muscarinic receptor system
N-hexacosanol diabetes-induced rat qualitative alteration muscarinic receptor system
2009/3/2
We evaluated the effects of N-hexacosanol, a cyclohexenonic long-chain fatty alcohol, on muscarinic receptors in diabetic rat ileal dysfunction. Eight-week-old male SD rats were divided into four gr...
Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts
Ischemia reperfusion dysfunction model-estimated kinetics myofilament interaction inotropic drugs
2010/2/26
We found that IR injury resulted in reduced myofilament Ca2+ sensitivity, and decreased cross-bridge association and dissociation rates. Dopamine (8 μM) reduced myofilament Ca2+ sensitivity before, bu...
Quantitative assessment of pain-related thermal dysfunction through clinical digital infrared thermal imaging
pain-related thermal dysfunction clinical digital infrared thermal imaging
2010/3/1
The wavelet domain-based Poisson noise removal techniques compared favourably against Wiener and other wavelet-based denoising methods, when qualitative criteria were used. It was shown to improve sli...