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Expression and Activities of Matrix Metalloproteinases under Oscillatory Shear in IL-1-Stimulated Synovial Cells
Expression Matrix Metalloproteinases
2014/11/13
Matrix metalloproteinases (MMPs) are known to play a critical role in tissue disintegration, and an elevated level of MMPs is observed in synovium and synovial fluid of joints with rheumatoid arthriti...
IL-33作用的靶细胞及其在寄生虫感染免疫中的作用
IL-33 靶细胞 寄生虫感染
2013/11/22
白细胞介素33（interleukin-33，IL-33）作为IL-1细胞因子家族的一个新成员，可以通过作用肥大细胞或Th2型细胞而发挥生物学功能。IL-33能诱导T细胞向Th2方向分化，激活肥大细胞、树突状细胞、嗜酸性粒细胞和嗜碱性粒细胞，增加相应细胞因子的表达，从而在机体的炎症性疾病和寄生虫感染造成的病理损伤中发挥重要作用。该文对IL-33作用的靶细胞及其在寄生虫感染免疫中的作用进行综述。
IFN-γ-, IL-4-, IL-17-, PD-1-Expressing T Cells and B Cells in Peripheral Blood from Tuberculosis Patients
Mycobacterium tuberculosis B Cells T Cells Th Cells PD-1
2013/1/28
Although the efficacy of tuberculosis (TB) vaccines is tightly linked to cell-mediated immunity, some functions of T and B cells in TB patients remain unclear. To address how Mycobacterium tuberculosi...
Objective Tripterygium wilfordii Hook.f.has been used for centuries in traditional Chinese medicine to treat autoimmune disease associated with increased production of the proinflammatory cytokine.Tr...
Schistosome eggs have a direct role in the induction of basophils capable of a high level of IL-4 production: Comparative study of single- and bisexual infection of Schistosoma mansoni in vivo
Schsitosoma mansoni Immunoregulation
2010/12/10
Immunobiological roles of schistosome eggs during murine experimental infection were investigated with special reference to the induction of basophilic leukocytes. After single- or bisexual infection ...
Novel models of cancer-related anemia in mice inoculated with IL-6-producing tumor cells
Novel models cancer-related anemia mice inoculated IL-6-producing tumor cells
2009/5/8
We established models of cancer-related anemia in mice from subcutaneous inoculation of two IL-6-producing cancer cell lines, human lung cancer cell line LC-06-JCK and murine colon26 clone 5 colon c...
Neutralization of IL-4 and IFN-γ Facilitates inducing TGF-β-induced CD4+Foxp3+ Regulatory Cells
suppressor/regulatory T cells cytokine Foxp3 autoimmunity
2009/4/29
It has been well recognized that TGF-β is able to induce CD4+CD25+Foxp3+ suppressor/regulatory T (iTreg) cells and IL-2 facilitates iTreg induction and expansion, however, only half of TGF-β-induced C...
IL-1β stimulates urokinase-type plasminogen activator expression and secretion in human dental pulp cells
IL-1β stimulates urokinase-type plasminogen activator expression secretion human dental pulp cells
2009/3/2
Plasminogen activator (PA) is the enzyme that converts plasminogen to its active form, plasmin, which is involved in various physiological and pathological phenomena. The conversion is catalyzed by ...