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心肌纤维化作为心衰的重要诱导因素，是由中重度冠状动脉粥样硬化性狭窄所引起的心肌纤维持续性和反复加重的心肌缺血、缺氧病变，全球每年有数十万人死于心肌纤维化导致的疾病。既往通过CAR-T细胞治疗心肌纤维化相关疾病时，由于该细胞在体内能存活数月甚至数年并持续攻击全身范围的成纤维细胞，从而导致伤口难以愈合，这大大限制了CAR-T疗法对心肌纤维化的治疗。
真核生物中，以RNAi为代表的小RNA介导的基因调控是一类重要的基因调控方式，该过程严格依赖于Dicer家族核酸酶切割前体RNA所产生的长度约为19-30 nt的小RNA。Dicer在小RNA的产生过程中，起到“分子尺”的功能，从前体RNA的一端测量特定的长度并切割产生特定的小RNA。过去二十多年，研究者们针对Dicer核酸酶开展了大量的系统研究，然而这个过程中Dicer作为一个整体是如何测量RN...
日前，生命科学学院河南大学-麦考瑞大学生物医学联合创新中心的最新研究论文“Blood-Brain Barrier Penetrating siRNA Nanomedicine for Alzheimer's Disease Therapy”被Science子刊《Science Advances》顺利接受。Science Advances为顶级学术期刊，目前其影响因子为13.116。阿尔茨海默症（俗...
Dr. Tamara Hayes，Professor of Department of Biomedical Engineering At Oregon Health & Science University（图）
Tamara Hayes Professor deliver health care
2009/12/24
Dr. Hayes' research interests include the use of ubiquitous computing to deliver health care in the home, with the goal of changing the current paradigm of clinic-centered healthcare to a model that i...
Dr. Steven Zucker，Professor of The Department of Biomedical Engineering at Yale University for Biomedical Engineering, Electrical Engineering & Comp.Science（图）
Steven Zucker Professor Biomedical Engineering Electrical Engineering
2009/12/22
Computational vision is at the heart of robotics and biomedicine, but it is primitive when compared with the human visual sense. Humans demonstrate, effortlessly, enormous visual flexibility and gener...
Shaping the future of science: plans revealed for new world-leading biomedical research institute in central London
the future of science new world-leading biomedical research institute central London
2009/12/14
The UK Centre for Medical Research and Innovation (UKCMRI), a groundbreaking project to create a world-leading biomedical research institute in central London, revealed its building designs and gave t...