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Long-term Downregulation of Protease-activated receptor-2 Expression in Distal Colon in Rats Following Bacillary Dysentery. Regulatory Peptides
PAR-2 Colonic smooth muscle Motility disorder
2014/5/16
The aim of this study was to determine changes of PAR-2 expression in distal colon and the sensitivity of colonic muscle to SLIGRL-NH2, the PAR-2-activating peptide (PAR-2-AP) following bacillary dyse...
PAR-2 Deficient CD4+ T Cells Exhibit Downregulation of IL-4 and Upregulation of IFN-γ after Antigen Challenge in Mice
CD4+ T cell GATA-3 JNK1 PAR-2 T-bet
2010/11/19
Background: To investigate the functional role of protease activated receptor (PAR) -2 in T lymphocytes, we analyzed TCR-mediated inflammatory cytokine production using PAR-2 deficient (KO) and wild t...
Genetic defects in downregulation of IgE production and a new genetic classification of atopy
atopy IgE production downregulation interferon-γ interleukin-12 receptor β2 interleukin-18 receptor α
2010/11/22
Atopic disorders, such as asthma, eczema and rhinitis, develop due to the interactions between genetic and environmental factors. Atopy is characterized by enhanced IgE responses to environmental anti...