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Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model
: PTEN Hamartoma Tumour syndrome Cowden syndrome
2015/12/21
PTEN Hamartoma Tumour Syndrome (PHTS) includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS),
and other conditions resulting from germline mutation of the PTEN tumour suppressor gene...
Lack of EGF receptor contributes to drug sensitivity of human germline cells
DNA damage epidermal growth factor receptor drug resistance
2014/12/12
Germline mutations have been associated with generation of various types of tumour. In this study, we investigated genetic alteration of germline tumours that affect the drug sensitivity of cells. Alt...
The Avian Germline and Strategies for the Production of Transgenic Chickens
primordial germ cells transgenic chickens chimeras blastoderm
2009/7/31
Considerable interest exists in the development of transgenic poultry as a means of improving commercial poultry stocks and for applications in the pharmaceutical industry. The development of transgen...
Cryopreservation of Avian Germline Cells and Subsequent Production of Viable Offspring
blastodermal cells cryopreservation germline chimaera primordial germ cells
2009/7/31
Cryopreservation of avian genetic material has become possible by preserving blastodermal cells or primordial germ cells. These germline cells can give rise to viable offspring via germline chimaeras....
New Screening Test for Male Germline Chimeric Chickens by Polymerase Chain Reaction Using Shingle Nucleotide Polymorphism Detection Primers
chimeric chicken germline mitochondrial DNA D-loop region single nucleotide polymorphism sperm
2009/7/31
Since it is impossible to distinguish germline chimeric chickens by appearance only, a progeny test is required for analyzing germline chimerism. To reduce the labor, time and expense involved in such...
Conservation of a Threatened Indigenous Fowl (Kureko Dori) Using the Germline Chimeras Transplanted from Primordial Germ Cells
endangered species domestic fowl germline chimera primordial germ cells transplantation
2009/7/30
This is the first successful report on producing the endangered domestic fowl, Kureko Dori (KD), which is a Kumamoto prefectural natural treasure, using germline chimeras transplanted from primordial ...
Restriction of Germline Proliferation by Soft X-ray Irradiation of Chicken Embryos and its Application to Chimera Production
blastoderm chimera embryo culture primordial germ cells soft x-ray
2009/7/30
Primordial germ cells (PGCs) are the progenitor cells of gametes. Avian PGCs are located in the central region of the area pellucida at the blastoderm stage. PGCs enter the circulation soon after the ...
Complete Regeneration of Muscular Dystrophy Chickens by Mating of Male and Female Offspring Derived from Germline Chimeras
chicken complete regeneration germline chimera muscular dystrophy
2009/7/29
In previous studies, two types of offspring were generated from germline chimera between NH-413 strain (donor) and White Leghorn L-M strain (recipient). Phenotype and symptom of type-I offspring were ...
Efficient Generation of Transgenic Rats Through the Male Germline Using Lentiviral Transduction and Transplantation of Spermatogonial Stem Cells
lentivirus spermatogenesis testis
2008/12/24
Spermatozoa produced from spermatogonial stem cells (SSCs) are the vehicle by which genes of a male are passed to the next generation. A single SSC has the ability to self-renew and produce thous...
Regulation of germline stem cell proliferation downstream of nutrient sensing
stem cell germline nutrient
2006/12/22
6 December 2006，Stem cells have recently attracted significant attention largely due to their potential therapeutic properties, but also because of their role in tumorigenesis and their resemblance, i...
Professor Cohen presents and analyzes a taxonomy of the potential harms of human genetic “germline engineering.” Germline engineering is the process of “artificially” and purposefully changing the gen...