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Blocking the CD154-CD40 interaction with anti-CD154 antibody differentially regulates interleukin-4 synthesis in T cells and IgE production in B cells
CD154 CD40 germline Cε IgE interleukin-4
2010/11/25
Using severe combined immunodeficiency mice engrafted with peripheral blood mononuclear cells from atopic patients, we analyzed the regulatory effects of anti-CD154 antibody on the in vivo induction o...
Genetic defects in downregulation of IgE production and a new genetic classification of atopy
atopy IgE production downregulation interferon-γ interleukin-12 receptor β2 interleukin-18 receptor α
2010/11/22
Atopic disorders, such as asthma, eczema and rhinitis, develop due to the interactions between genetic and environmental factors. Atopy is characterized by enhanced IgE responses to environmental anti...