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搜索结果: 1-15 共查到Myostatin相关记录38条 . 查询时间(0.062 秒)
Myostatin (MSTN) can negatively regulate the growth and development of skeletal muscle, and natural mutations can cause “double-muscling” trait in animals. In order to block the inhibiting effect of M...
Myostatin (MSTN) is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Gene knockout of MSTN can result in increasing muscle mass ...
After four days of differentiation, myotubes were treated with MSTN (10 ng/ml) for two additional days and four treatment groups were studied: 1) 3x per day 10 mM Leu, 2) 3x per day 10 mM HMB, 3) 3x p...
The main objective of this study was to reveal the expression profiles of two negative regulators, myostatin (MSTN) and calpastatin (CAST)genes, of skeletal muscle growth in highland yaks (Bos grunnie...
To investigate the feasibility of developing a method for detection of gene doping in power-athletes, we devised an experimental model system.
Myostatin is considered to be one of the most powerful negative regulators of muscle growth. The lack of a functional myostatin or its mutation can result in uncommon musculature like “double-muscling...
Eccentric contractions produce a significant degree of inflammation and muscle injury that may increase the expression of myostatin. Due to its anti- oxidant and anti-flammatory effects, circulating 1...
he present study determined the effects of concentric and eccentric muscle actions on the contents of serum myostatin and follistatin-like related gene (FLRG). Eight untrained males performed one ex...
旨在探究绵羊胚胎中后期骨骼肌BTG2/3(B cell translocation gene 2/3)的动态表达情况,探索肌肉生长抑制素(MyostatinMSTN)基因对其表达的影响。以特克赛尔(Texel)和乌珠穆沁(Ujimqin)绵羊85、100、120和135 d 4个不同发育阶段的胎儿背最长肌为研究对象,利用Real-time PCR技术分别检测MSTN及BTG2/3的表达差异;选取...
为阐明Myostatin在肌原纤维损伤中的作用,并探讨提高畜禽肉产(质)量或控制人类肌肉萎缩的方法,本试验以小鼠为模式动物,采用高剂量地塞米松构建了严重应激模型,研究生理剂量胰岛素对地塞米松致肌原纤维损伤的影响及其与Myostatin基因表达的关系,以及Myostatin基因免疫对地塞米松致肌原纤维损伤的干预作用。结果表明:地塞米松诱导Myostatin基因表达上调及严重的肌原纤维损伤和线粒体肿胀...
试验克隆了崂山奶山羊Myostatin基因序列,构建了其真核表达载体,并验证了其在成纤维细胞中的表达。本研究通过从崂山奶山羊肌肉组织中提取RNA,反转录后采用巢式PCR方法扩增出Myostatin基因序列,构建真核表达载体,通过转染成纤维细胞,采用RT-PCR方法验证其表达。结果表明,克隆出崂山奶山羊Myostatin基因的全长cDNA序列,大小为1128 bp,GenBank登录号:GU3773...
旨在获得肌肉生长抑制素(MyostatinMSTN)基因沉默的成纤维细胞系,为进一步探索Myostatin的调控机理,获得 Myostatin的基因沉默的转基因羊奠定基础。针对小尾寒羊Myostatin的基因序列,设计4条siRNA干扰序列,构建pSilencer干扰载体,转染成纤维细胞,采用RTPCR进行筛选;构建慢病毒干扰载体,包装病毒,感染成纤维细胞,采用流式细胞技术分选阳性细胞,阳性细...
Myostatin, which is also known as growth and differentiation factor 8 (GDF8), has been reported to act as a negative regulator of skeletal muscle development. Variation in the myostatin gene (MSTN) ha...
Myostatin基因属于TGF β超家族,是动物骨骼肌生长发育的负调控因子。在已克隆大黄鱼Myostatin-1基因编码序列的基础上,采用基因组步移的方法,首次克隆到约1k bp的大黄鱼Myostatin-1启动子序列。该启动子序列与已报道的金鲷和大口黑鲈相应序列的相似度分别为90%和75%。该序列具有1个TATA box、1个CAAT box、5个E-box位点,此外还具有MyoD,USF,M...
根据Myostatin基因的保守性,选择牛(Bos taurus cattle 登录号:AB076403)的Myostatin序列为模板进行引物设计,首次从东北马鹿基因组中扩增出Myostatin序列,扩增产物连接pMD18T载体,克隆出3个外显子片断。根据5′-GU-AG-3′规则和同源基因比对拼接出完整的编码序列,全长为1 128 bp(发表到GenBank 登录号:EF629535),My...

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