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Electronic cigarette aerosols induce oxidative stress-dependent cell death and NF-kappa B mediated acute lung inflammation in mice
Electronic cigarette aerosol Acute lung inflammation Oxidative stress NF-κ b pathway Aldehyde
2023/6/21
Electronic cigarette (e-cigarette) use has been linked to recent acute lung injury case clusters in over 2000 patients and dozens of deaths in the United States, however, the mechanism leading to lung...
Mice have long been a central part of neuroscience research, providing a flexible model that scientists can control and study to learn more about the intricate inner workings of the brain. Historicall...
New poo, new you? Fecal transplants reverse signs of brain aging in mice
fecal transplant brain aging health
2021/8/10
As you age, your brain slows down. You may forget where you left your glasses or have trouble picking up a new skill. Now there’s hope from rodent experiments that some of these declines could be reve...
Fasting may help ward off infections, study in mice suggests
fasting infection prevention salmonella
2021/8/6
Fasting before and during exposure to Salmonella enterica bacteria protects mice from developing a full-blown infection, in part due to changes in the animals' gut microbiomes, according to new resear...
Every time we reach for a cup, our brains must assess our hands’ current position in relation to the mug and then command muscles to make the proper adjustments to successfully grab the handle.
Scientists show jet lag impairs immune response in mice（图）
jet lag impairs immune response mice
2020/10/23
Imagine you've just arrived in Paris. Your body thinks it should be midnight -- a restorative time when your cells typically proofread DNA, organize and store energy, and perform other essential chore...
Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2
SARS-CoV-2 human ACE2 transgenic mouse COVID-19 pneumonia
2020/6/11
COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV-2) that uses human angi...
复旦大学历史学系旅游市场研究课件Case-Chapter-5 Shanghai Changning MICE
复旦大学历史学系 旅游市场研究 课件 Case-Chapter-5 Shanghai Changning MICE
2019/4/2
复旦大学历史学系旅游市场研究课件Case-Chapter-5 Shanghai Changning MICE。
Scientists have successfully regenerated cells in the retina of adult mice at the University of Washington School of Medicine in Seattle.Their results raise the hope that someday it may be possible to...
Exercise Training Reverses Extrapulmonary Impairments in Smoke-exposed Mice
DIAPHRAGM SKELETAL MUSCLE ENDOTHELIUM HIGH-INTENSITY INTERVAL TRAINING MITOCHONDRIAL FUNCTION COPD
2018/4/24
Purpose Cigarette smoking is the main risk factor for chronic obstructive pulmonary disease and emphysema. However, evidence on the extrapulmonary effects of smoke exposure that precede lung impairmen...
Exercise Attenuates High-Fat Diet–induced Disease Progression in 3xTg-AD Mice
INSULIN RESISTANCE EXERCISE TRAINING ALZHEIMER'S DISEASE COGNITIVE DECLINE
2018/4/24
Purpose Little is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimer's disease (AD) and AD-like cognitive deficits. This study aimed to investigat...
In a possible step forward for gene therapy,Stanford researchers made mice glow like fireflies
step forward gene therapy Stanford researchers mice glow fireflies
2017/3/14
Timothy Blake, a postdoctoral fellow in the Waymouth lab, was hard at work on a fantastical interdisciplinary experiment. He and his fellow researchers were refining compounds that would car...
Oral administration of heat killed Tsukamurella inchonensis enhances immune responses and intestinal function in mice
immunomodulation delayed type hypersensitivity haemagglutination titre intestine villus histology liver spleen kidney
2016/12/8
We studied the effects of heat-killed Tsukamurella inchonensis on immune parameters and intestinal structure in mice. Mice were treated with three doses of bacteria (5 × 107, 1 × 108 and 2 × 108 CFU/m...
New Gene-Editing Technology Cures Genetic Blood Disorder in Mice
New Gene-Editing Technology Cures Genetic Blood Disorder Mice
2016/11/4
A next-generation gene-editing system developed by Carnegie Mellon University and Yale University scientists has cured a genetic blood disorder in living mice using a simple IV treatment. Unlike the p...
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development
birth defects developmental defects embryo folic acid high folate methylenetetrahydrofolate reductase MTHFD1 placenta
2018/12/19
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydro...