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Targeted introduction of heritable point mutations into the plant mitochondrial genome
plant mitochondrial genome heritable ALEN-GDM mtDNA genome editing CRISPR-Cas
2023/11/28
The development of technologies for the genetic manipulation of mitochondrial genomes remains a major challenge. Here we report a method for the targeted introduction of mutations into plant mitochond...
Complete Mitochondrial Genome Sequences of Chinese Indigenous Sheep with Different Tail Types and an Analysis of Phylogenetic Evolution in Domestic Sheep
Mitochondrial DNA Mitogenome Sheep Phylogenetic Mitochondrial Control Region
2016/5/20
China has a long history of sheep (Ovis aries [O. aries]) breeding and an abundance of sheep genetic resources. Knowledge of the complete O. aries mitogenome should facilitate the study of the evoluti...
Complete Nucleotide Sequence of Numida meleagris (Helmeted Guineafowl) Mitochondrial Genome
complete nucleotide sequence genetic diversity mitochondrial DNA Numida meleagris phylogenetic analysis
2009/7/31
Guineafowl has been classified into the order Galliformes. However, little genetic information was available to establish the phylogenetic position of the Guineafowl. In the present study we subjected...
Complete Nucleotide Sequence of Mitochondrial Genome in Silkie Fowl (Gallus gallus var.domesticus
whole mitochondrial DNA Silkie fowl phylogenetic analysis
2009/7/31
Whole mitochondrial DNA of the Silkie fowl (Gallus gallus var. domesticus) was sequenced in order to elucidate the genetic position of the Silkie fowl in its related species based on mitochondrial DNA...
MITOMAP-A human mitochondrial genome database
human mitochondrial DNA mitochondrial genome
2008/1/16
A compendium of polymorphisms and mutations of the human mitochondrial DNA.
胞质异质性——人类肿瘤组织线粒体基因突变的普遍现象Heteroplasmy: A Common Phenomenon of Mitochondrial Genome Mutations in Human Tumor Tissues
线粒体基因 突变 异质性 同质性 肿瘤
2008/1/6
为了探讨不同肿瘤组织中线粒体基因体细胞性突变的胞质异质性和同质性状态，利用32对重叠引物对149例肿瘤组织和匹配的正常组织的全线粒体基因进行PCR扩增，并同时进行时相温度梯度凝胶电泳扫描突变筛选，基因测序确定突变类型与异质状况。结果表明，不同肿瘤组织中线粒体基因体细胞性突变的异质率不同，口腔癌（65%）和食道癌（64%）具有较高的异质率，其次为乳腺癌（45.9%）。4种转换形式的发生频率Hm→Hm...