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The Boston area has long been home to innovation that leads to impactful new drugs. But manufacturing those drugs for clinical trials often involves international partners and supply chains. The vulne...
Effects of isolated soluble fiber supplementation on body weight, glycemia, and insulinemia in adults with overweight and obesity: a systematic review and meta-analysis of randomized controlled trials
body composition glucose insulin meta-analysis soluble fiber supplementation
2018/11/21
Background: There is strong epidemiologic evidence that dietary fiber intake is protective against overweight and obesity; however, results of intervention studies have been mixed. Soluble fiber benef...
Comparison among criteria to define successful weight-loss maintainers and regainers in the Action for Health in Diabetes (Look AHEAD) and Diabetes Prevention Program trials
Diabetes Prevention Program Look AHEAD weight-loss maintenance lifestyle modification weight regain
2018/11/20
Background: Given the low rates of successful weight maintenance after lifestyle-induced weight loss, it is critical to develop approaches that distinguish successful weight-loss maintainers from rega...
Pomegranate juice, but not an extract, confers a lower glycemic response on a high–glycemic index food: randomized, crossover, controlled trials in healthy subjects
carbohydrate digestion glucose transport glycemic index polyphenol starch
2018/11/21
Background: Low–glycemic index diets have demonstrated health benefits associated with a reduced risk of developing type 2 diabetes.
The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials
blood pressure cardiovascular diseases insulin resistance
2018/11/19
Background: To our knowledge, the effect of magnesium supplementation on blood pressure (BP) in individuals with preclinical or noncommunicable diseases has not been previously investigated in a meta-...
The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials
blood pressure cardiovascular diseases insulin resistance
2018/11/16
Background: To our knowledge, the effect of magnesium supplementation on blood pressure (BP) in individuals with preclinical or noncommunicable diseases has not been previously investigated in a meta-...
A review of the characteristics of dietary fibers relevant to appetite and energy intake outcomes in human intervention trials
weight management appetite regulation viscosity gelling fermentability molecular weight dietary fiber properties
2018/11/19
Background: Many intervention studies have tested the effect of dietary fibers (DFs) on appetite-related outcomes, with inconsistent results. However, DFs comprise a wide range of compounds with diver...
A review of the characteristics of dietary fibers relevant to appetite and energy intake outcomes in human intervention trials
weight management appetite regulation viscosity gelling fermentability molecular weight dietary fiber properties
2018/11/16
Background: Many intervention studies have tested the effect of dietary fibers (DFs) on appetite-related outcomes, with inconsistent results. However, DFs comprise a wide range of compounds with diver...
Pretreatment fasting plasma glucose and insulin modify dietary weight loss success: results from 3 randomized clinical trials
glucose insulin precision medicine personalized nutrition weight glycemic load glycemic index fiber prediabetes diabetes
2018/11/15
Background: Which diet is optimal for weight loss and maintenance remains controversial and implies that no diet fits all patients.
Effects of free sugars on blood pressure and lipids: a systematic review and meta-analysis of nutritional isoenergetic intervention trials
blood pressure cholesterol triacylglycerols body weight free sugars complex carbohydrates ntervention trials meta-analysis
2018/11/12
Background: Sugar has been suggested as a central risk factor in the development of noncommunicable diseases.
Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials
allergic disease n–3 LC-PUFA pregnancy allergy prevention fatty acids randomized controlled trial prenatal supplementation asthma eczema hayfever
2018/11/23
Background: There is some evidence that increased maternal intake of omega-3 (n–3) long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may reduce the incidence of immunoglobulin E (IgE)...
Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials
dietary guidance blood lipids blood lipoproteins blood pressure animal flesh meat products diet meat
2018/11/12
Background: Observational associations between red meat intake and cardiovascular disease (CVD) are inconsistent. There are limited comprehensive analyses of randomized controlled trials (RCTs) that i...
Effect of fructose consumption on insulin sensitivity in nondiabetic subjects: a systematic review and meta-analysis of diet-intervention trials
fructose glucose clamp glucose disposal insulin insulin resistance meta-analysis
2018/12/19
Background: High fructose consumption has been suggested to contribute to several features of metabolic syndrome including insulin resistance, but to our knowledge, no previous meta-analyses have inve...
Do ω-3 PUFAs affect insulin resistance in a sex-specific manner? A systematic review and meta-analysis of randomized controlled trials
adults diabetes omega-3 PUFAs DHA EPA insulin resistance insulin sensitivity
2018/12/19
Background: Evidence has suggested that omega-3 (n–3) polyunsaturated fatty acids (PUFAs) improve obesity-induced insulin resistance (IR); however, results from human intervention trials have been equ...
Vitamin D status and weight loss: a systematic review and meta-analysis of randomized and nonrandomized controlled weight-loss trials
meta-analysis obesity serum 25-hydroxyvitamin D vitamin D weight loss
2018/12/14
Background: Obesity is associated with lower concentrations of serum 25-hydroxyvitamin D; however, uncertainty exists as to the direction of causation. To date, meta-analyses of randomized controlled ...