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染色质重塑主要包括围绕核小体的组蛋白修饰和染色质重塑蛋白介导的染色质构型调控。染色质重塑介导的基因转录表达调控是植物基因转录调控最重要的调控机制之一。然而,目前对于病原菌侵染诱导的寄主植物核小体动态变化及其与基因转录表达的关系尚不清楚。
Background: Weight loss (WL) is often followed by weight regain after an energy-restricted dietary intervention (DI). When people are following a diet, the volume of an adipocyte decreases by loss of ...
The process of active paternal chromatin demethylation after fertilization in the pig is not fully understood and very inconsistent data have been published by different research groups. We have app...
Under normal conditions, smooth muscle cells do not replicate, or proliferate, and provide a means of contraction for many internal organs, including blood vessels and the gut. However, under abnormal...
Introduction Bone turnover suppression in sites that already have a low surface-based remodeling rate may lead to oversuppression that could have negative effects on the biomechanical properties of bo...
Bisphosphonates suppress bone remodeling activity, increase bone volume, and significantly reduce fracture risk in individuals with osteoporosis and other metabolic bone diseases. The objectives of th...
Objective –  The pathophysiology of osteonecrosis of the jaw (ONJ) is thought to be linked to suppression of intracortical remodeling. The aim of this study was to determine whether mice, ...
由组织暑期学校将于2014年6月23至27日在意大利乌迪内举办,该暑期学校主题为“Multiscale Mechanobiology of Bone Remodeling and Adaptation”,现已开放注册,可在CISM网站(http://www.cism.it/courses/C1406/)上获得更多信息。
Macrophages have recently been characterized as having an M1 or M2 phenotype based on receptor expression, mechanism of activation and function. The effects of macrophage phenotype upon tissue remodel...
Abstract: The aim of this paper is to develop a multiscale hierarchical hybrid model based on finite element analysis and neural network computation to link mesoscopic scale (trabecular network level)...
RSC is an essential chromatin remodeling factor that is required for the control of several processes including transcription, repair and replication. The ability of RSC to relocate centrally position...
Bone remodeling is regulated by pathways controlling the interplay of osteoblasts and osteoclasts. In this work, we apply the method of generalized modelling to systematically analyse a large class o...
The response of bSMC migration to bSMC-conditioned medium increased with time in culture, and fibronectin (FIB) was detected as a chemoattractant for bSMCs in bSMC-conditioned medium by western blot a...
Recent studies have identified extracellular matrix (ECM) compliance as an influential factor in determining the fate of anchorage-dependent cells. We explore a method of examining the influence of E...
Progress in tissue-engineering research has renewed optimism about the possibility of constructing a physiologically functional blood vessel substitute in the laboratory. To this end, we have explore...

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