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北京大学生命科学学院张传茂实验室揭示Hedgehog信号通路蛋白Sufu同时负调控中心体复制和DNA复制起始的分子机制(图)
北京大学生命科学学院 张传茂 Hedgehog 信号通路蛋白 中心体 DNA
2021/7/12
2021年07月13日,北京大学生命科学学院张传茂教授实验室在《美国科学院院刊》(PNAS)上长文在线发表题为“Sufu negatively regulates both initiations of centrosome duplication and DNA replication”的研究论文。该项工作发现Sufu独立于其在Hedgehog信号通路中的经典功能,作为一个主控开关(“maste...
刺猬信号通路(Hh)首先在普通果蝇中被鉴定,是一种高度保守的信号从细胞膜传递到细胞核的进化途径,其传导失调被证实与一系列恶性肿瘤的发生、发展相关。丝氨酸/苏氨酸激酶Fused抑制物(Sufu)是Hh信号通路的关键调控因子,主要通过调节该通路的末端转录因子胶质瘤相关癌基因同源物(Gli)的表达来抑制Hh信号通路,起肿瘤抑制因子作用。本文主要就Sufu调控Hh信号通路的分子机制以及Sufu蛋白自身活性...
Antioxidative and Angiotensin I-Converting Enzyme Inhibitory Activities of Sufu (Fermented Tofu) Extracts
antioxidation tofuyo
2009/9/10
Tofuyo and sufu are fermented tofu products which are popular in Okinawa, Japan and in China,
respectively. Water extracts from 4 types of tofuyo (produced in Okinawa, Japan) and one type of sufu (pr...
Radical-Scavenging Activity and Isoflavone Content of Sufu(Fermented Tofu)Extracts from Various Regions in China
radical-scavenging activity sufu isoflavone
2009/6/18
Water extracts and 50% ethanol extracts of 14 samples of sufu (fermented tofu) produced in various regions of China were prepared, and their DPPH (α,α-Diphenyl-β-pricryl-hydrazyl) radical-scavenging a...