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科学家揭示人三磷酸腺苷依赖的RNA解旋酶A在抗病毒免疫中的作用
人三磷酸腺苷 RNA解旋酶A 抗病毒免疫
2024/1/18
人三磷酸腺苷（ATP）依赖的核糖核酸（RNA）解旋酶A（DHX9）是一种多功能核蛋白，广泛参与RNA的加工、转录和翻译。研究表明，DHX9可以与细胞核中的亚基结合，促进下游促炎细胞因子转录，抵抗脱氧核糖核酸（DNA）病毒感染，且多种病毒劫持DHX9以逃避先天免疫系统并促进自我复制。但是，DHX9能否在调节细胞核中针对RNA病毒的先天免疫发挥作用尚不清楚。近日，中国科学技术大学、广州医科大学和耶鲁大...
科学家首次发现促进肌动蛋白成熟的蛋白酶
肌动蛋白 成熟 蛋白酶
2024/1/23
肌动蛋白参与肌肉收缩、细胞分裂和细胞运动等重要生理过程，但是肌动蛋白如何从非活性的前体被加工成为活性状态尚待揭示。荷兰癌症研究所的科研人员发现了一种调控肌动蛋白成熟的蛋白酶。相关成果在《Science》发表，论文的标题为：Actin maturation requires the ACTMAP/C19orf54 protease。
New programmable gene editing proteins found outside of CRISPR systems（图）
CRISPR系统 可编程基因 编辑蛋白 酶
2023/6/20
Within the last decade, scientists have adapted CRISPR systems from microbes into gene editing technology, a precise and programmable system for modifying DNA. Now, scientists at MIT’s McGovern Instit...
Nitrogen, an element that is essential for all living cells, makes up about 78 percent of Earth’s atmosphere. However, most organisms cannot make use of this nitrogen until it is converted into ammoni...
Nature-inspired CRISPR enzymes for expansive genome editing（图）
CRISPR酶 基因组编辑 应用计算生物学 DNA序列
2023/6/19
In nature, bacteria use CRISPR as an adaptive immune system to protect themselves against viruses. Over the past decade, scientists have been able to successfully build upon that natural phenomenon wi...
April 27, 2007，Building a balanced portfolio for energy production is not simply a matter of applying known science to large-scale engineering applications, according to George Whitesides, one of the ...