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2017 “健康和疾病翻译机”高登研究研讨会（The Gordon Research Seminar on Translation Machinery in Health and Disease）
Health Disease
2017/3/8
The Gordon Research Seminar on Translation Machinery in Health and Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education t...
Longitudinal study of alcohol consumption and HDL concentrations: a community-based study
alcohol cardiovascular disease risk epidemiology HDL lipids prospective cohort triglyceride
2018/11/13
Background: In cross-sectional studies and short-term clinical trials, it has been suggested that there is a positive dose-response relation between alcohol consumption and HDL concentrations. However...
The role of gluten consumption at an early age in celiac disease development: a further analysis of the prospective PreventCD cohort study
celiac disease children gluten HLA European cohort
2018/11/13
Background: We previously found that the introduction of small quantities of gluten at 4–6 mo of age did not reduce the risk of celiac disease (CD) in a group of high-risk children. However, the consu...
Dietary protein is associated with musculoskeletal health independently of dietary pattern: the Framingham Third Generation Study
bone mineral density dietary patterns dietary protein muscle mass muscle strength
2018/11/13
Background: Above-average dietary protein, as a single nutrient, improves musculoskeletal health. Evaluating the link between dietary protein and musculoskeletal health from a whole-diet perspective i...
Determining the protein needs of “older” persons one meal at a time
protein requirement older persons
2018/11/12
The determination of protein requirements (need) and “optimal” protein intakes (greater than need but beneficial to health) is complex and currently, insofar as older persons are concerned, without co...
研究抗衰老Klotho蛋白对过氧化氢(H2O2)氧化损伤的人脐静脉内皮细胞(HUVEC)的影响及其作用机制。 方法 用H2O2诱导HUVEC构建氧化损伤模型。将HUVEC设置对照组、H2O2损伤组、不同浓度(1、10、100 μg/L)Klotho蛋白组、丝氨酸-苏氨酸蛋白激酶(AKT)作用组。噻唑蓝法检测细胞存活率；特定试剂盒检测乳酸脱氢酶(LDH)、丙二醛(MDA)、超氧化物歧化酶(SOD)、...
Breaking down, starting up: can a vitamin C–enriched gelatin supplement before exercise increase collagen synthesis?
vitamin C–enriched gelatin collagen synthesis
2018/11/12
Obesity is a major challenge to maintaining health (1) and is associated with the metabolic syndrome, whose components include diabetes, hypertension, and hypercholesterolemia (2, 3). Complications fr...
Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men
doubly labeled water energy requirement resting energy expenditure short bowel syndrome total energy expenditure
2018/11/26
Background: Increasing skeletal muscle carnitine content represents an appealing intervention in conditions of perturbed lipid metabolism such as obesity and type 2 diabetes but requires chronic L-car...
Habituation to low or high protein intake does not modulate basal or postprandial muscle protein synthesis rates: a randomized trial
habitual protein intake muscle protein synthesis protein digestion stable-isotope tracers whey protein
2018/11/12
Background: Muscle mass maintenance is largely regulated by basal muscle protein synthesis rates and the ability to increase muscle protein synthesis after protein ingestion. To our knowledge, no prev...
Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis
bone exercise ligament tendon inury prevention return to play
2018/11/12
Background: Musculoskeletal injuries are the most common complaint in active populations. More than 50% of all injuries in sports can be classified as sprains, strains, ruptures, or breaks of musculos...
探讨载脂蛋白A5 (ApoA5)基因c.553G/T位点多态性与遵义汉族人群高胆固醇血症(HTC)的相关性。 方法 采用聚合酶链反应限制性片长多态性(PCR-RFLP)技术检测并分析101例HTC患者和118例正常对照者ApoA5基因c.553G/T位点多态性。 结果 两组中ApoA5基因 c.553G/T位点基因型频率差异有统计学意义(P<0.05),ApoA5 c.553T基因在HTC患者组中...
目的：探讨牡蛎肽对免疫抑制小鼠的免疫调节作用及可能机制。方法：以环磷酰胺（cyclophosphamide，CTX）致免疫低下雌性ICR小鼠为动物模型，观察不同剂量牡蛎肽（0.5 g/kg低剂量组、1.0 g/kg中剂量组、2.0 g/kg高剂量组）干预15 d后对小鼠体重、免疫器官相对重量、免疫器官显微结构、外周血白细胞数目、T淋巴细胞亚群百分比、血清中的细胞因子浓度以及骨髓有核细胞数和DNA含...
Short Hydrogen Bonds and Proton Delocalization in Green Fluorescent Protein (GFP)
Short Hydrogen Bonds Proton Delocalization Green Fluorescent Protein GFP
2016/5/25
Short hydrogen bonds and specifically low-barrier hydrogen bonds (LBHBs) have been the focus of much attention and controversy for their possible role in enzymatic catalysis. The green fluorescent pro...
Choose Your Label wisely:Water-Soluble Fluorophores Often Interact with Lipid Bilayers
Water Proteins Lipid Bilayers Fluorescent Dyes Spectrometry, Fluorescence Protein Binding Solubility
2016/5/25
Water-soluble organic fluorophores are widely used as labels in biological systems. However, in many cases these fluorophores can interact strongly with lipid bilayers, influencing the interaction of ...
Thermodynamics,Kinetics,and Photochemistry of Beta-Strand Association and Dissociation in a Split-GFP System
Green Fluorescent Proteins Protein Structure,Secondary Kinetics Photochemistry Thermodynamics Models, Molecular
2016/5/25
Truncated green fluorescent protein (GFP) that is refolded after removing the 10th β-strand can readily bind to a synthetic strand to recover the absorbance and fluorescence of the whole protein. This...