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CELL FUSION
CELL FUSION
2015/3/4
Just as human relationships are a two-way street, fusion between cells requires two active partners: one to send protrusions into its neighbor, and one to hold its ground and help complete the process...
Studies of bovine B cell development
B cells cells animals old animals spleen gene rearrangement
2014/12/11
This dissertation was to study the sites of B cell development, the mechanisms of Ig diversification, the time when diversification occurs, the B cell repertoire during development and usage of Ig lig...
The role of mitochondria and proteasomes in T cell apoptosis
Cell apoptosis cell death cell biology enzyme hydrolysis T cells
2014/12/11
Apoptosis is a type of programmed cell death that is essential for the development and maintenance of tissue homeostasis in multicellular organisms. Because apoptosis is important in many biological s...
The role of cell cycle progression and cyclin -dependent kinase 2 in thymocyte negative selection
T cells and thymus cells thymus self antigen cells
2014/12/11
Autoreactive, immature T cells (thymocytes) are deleted from the thymus during development by the process of negative selection. This mechanism occurs when the thymocyte, T cell receptor (TCR) recogni...
The effect of dominant negative EGR-1 and hyperbaric oxygen on immune cell apoptosis
Induction of cells and multicellular organisms physiology cell death cell research gene regulation
2014/12/11
The ultimate means of limiting the influence of an individual cell on the physiology of a multicellular organism is to induce the death of that cell. Apoptosis is a genetically regulated form of cell ...
Analysis of programmed cell death in Drosophila
Genes cells activate gene expression system central nervous system cell death protein
2014/12/11
The Drosophila reaper, head involution defective ( hid), and grim genes play key roles in regulating the activation of programmed cell death. In this first part of this study we use the Gal4/UAS targe...
Characterization of arachidonic acid -mediated signal transduction in regulation of NIH -3T3 cell adhesion to extracellular matrix
Matrix the discrete form cells cell proliferation lipid protein cell fibronectin
2014/12/11
Cell-extracellular matrix (ECM) adhesion is characterized by discrete morphological and functional stages beginning with cell-substrate attachment, followed by cell spreading and then migration. These...
Overlapping and distinct functions for Gli proteins: Key mediators of hedgehog signaling in cell specification during embryonic development
Signals embryonic tissue cell differentiation the central nervous system the pituitary gland the pancreas cells
2014/12/11
Hedgehog (Hh) signaling is important for patterning and cell differentiation within many embryonic tissues. Hh is expressed in the notochord and the floor plate and acts as a morphogen in patterning o...
Cyclooxygenase and cyclic AMP -dependent protein kinase regulate actin organization and cell motility
Cells extracellular matrix cell signal cytoskeleton the cancer cells
2014/12/11
Cell adhesion to an extracellular matrix plays a critical role in many aspects of normal cell function. Cells display various modes of interaction with the extracellular matrix; they may attach and sp...
The role of Notch in T cell activation and development
To activate T cells incision p53 intracellular domain HES1 genes
2014/12/11
Notch is crucial for multiple stages of T cell development, including the CD4+CD8+ double positive (DP) to CD8 + single positive (SP) transition, but regulation of Notch activation is not well underst...
Notch functions from the cytoplasm to the nucleus during T cell activation
Cytokines T cells activate cells cell signal
2014/12/11
Notch1 specifically upregulates expression of the cytokine interferon-γ in peripheral T cells through activation of NF-κB. However, how Notch mediates NF-κB activation remains unclear. NF-κB activatio...
Regulation of Notch signaling by the E3 ubiquitin ligase Cbl-b and its role in CD4+ T cell anergy
Cell life cycle T cell signal T cell activation and E3 ubiquitin ligase
2014/12/11
Notch signaling is an evolutionarily conserved pathway that mediates a variety of cell fate decisions. In the immune system, the Notch pathway plays an important role throughout the life of T cells. C...
WC1 mediates T cell activation and is required for the response of bovine gammadelta T cells to Leptospira antigen
Biological sciences T cell activation Leptospira
2014/12/11
Workshop cluster 1 (WC1) molecules are exclusively expressed on the surface of γδ T cells. They belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a multiple-gene fam...
Beyond cell Adhesion: Exploring the Role of Cadherin-11 Extracellular Processing by ADAM Metalloproteases in Cranial Neural Crest Migration
ADAM Cadherin Cell migration Cell signaling Cranial neural crest Developmental biology/Embryology
2014/12/10
The migration of the cranial neural crest is an essential part of cranio-facial development in every vertebrate embryo. The cranial neural crest (CNC) is a transient population of cells that forms the...
Effects of Phytochemicals from Rhodiola crenulata on Highly Invasive Breast Cancer Cell Lines and Embryonic Models of Migration
Cancer Mammary Metabolism Metastasis Natural Product Rhodiola crenulata
2014/12/10
The root of the Tibetan plant Rhodiola crenulata is part of eastern traditional medicine. Studies have suggested that members of the Rhodiola genus display anticancer properties. In this study we exam...