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Study reports repair of mitochondrial recycling defect linked to Parkinson’s disease
dopamine PD mitochondria recovery
2021/8/11
A study in mice shows that an experimental small molecule helped restore the removal of damaged mitochondria from dopamine-producing brain cells.
Light-activated 'CRISPR' enables fast, precise gene editing and detection of DNA repair(图)
Light-activated CRISPR enables fast precise gene editing detection DNA repair
2020/7/3
In a series of experiments co-funded by the National Science Foundation, scientists at Johns Hopkins have used light as a trigger to make quick, precise cuts in the genomic material of ...
Stanford scientists create a cellular guillotine for studying single-cell wound repair
Stanford scientists cellular guillotine single-cell wound repair
2017/7/24
While doing research at the Woods Hole Marine Biological Laboratory in Massachusetts, Sindy Tang learned of a remarkable organism: Stentor coeruleus. It’s a single-celled, free-living f...
2017组织修复和再生高登研究研讨会(The Gordon Research Seminar on Tissue Repair & Regeneration)
Tissue Repair Regeneration
2017/3/7
Applications for this meeting must be submitted by May 6, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be sta...
2017 基因组不稳定性和DNA修复 Keystone Symposia(2017 Keystone Symposia on Genomic Instability and DNA Repair)
Genomic Instability DNA Repair
2017/3/7
The meeting will begin on Sunday, April 2 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 6 with a closing plenary session ...
2017哺乳动物DNA修复高登研究研讨会(The Gordon Research Seminar on Mammalian DNA Repair)
2017 哺乳动物DNA修复高登研究 研讨会
2017/2/13
The Gordon Research Seminar on Mammalian DNA Repair is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange ...
Metnase is a novel bifunctional protein that contains a SET domain and a transposase domain. Metnase contains sequence-specific DNA binding activity and sequence non-specific DNA cleavage activity, as...
ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU80 C-TERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU
DNA-PKcs regulation Ku NHEJ
2015/5/25
DNA double strand breaks (DSB) are among the most lethal forms of DNA damage and can occur as a result of ionizing radiation (IR), radiomimetic agents, endogenous DNA-damaging agents, etc. If left unr...
The influence of the Ku80 carboxy-terminus on activation of the DNA-dependent protein kinase and DNA repair is dependent on the structure of DNA cofactors
DNA-PK Ku70/80 Ku80 Carboxy Terminus
2015/5/25
In mammalian cells DNA double strand breaks (DSBs) are highly variable with respect to sequence and structure all of which are recognized by the DNA- dependent protein kinase (DNA-PK), a critical comp...
New lab technique simultaneously reveals structure and function of proteins critical in DNA repair
structure and function proteins critical DNA repair
2015/4/29
By combining two highly innovative experimental techniques, scientists at the University of Illinois at Urbana-Champaign have for the first time simultaneously observed the structure and the correlate...
Damaged DNA may stall patrolling molecule to initiate repair(图)
Damaged DNA stall patrolling molecule initiate repair
2015/3/4
Sites where DNA is damaged may cause a molecule that slides along the DNA strand to scan for damage to slow on its patrol, delaying it long enough to recognize and initiate repair. The findi...
Replication and 3'-end repair of a subviral RNA associated with turnip crinkle virus
RNA virus satellite RNA radish virus
2014/12/11
Replication of plus (+)-strand RNA viruses proceeds through minus (−)-strand intermediates. Satellite RNA C (satC), one of the nonessential subviral RNAs of Turnip crinkle virus (TCV), is depend...
Probing for Conformational Changes in the Repair Enzyme Mfd Using Mutant Protein Constructs
Conformational Changes Repair Enzyme Mfd Mutant Protein Constructs
2014/12/9
DNA repair is essential for survival, as damage to the genome can interrupt the precarious balance of cell functions, causing further mutations and possibly leading to cancer. The bacterial transcript...
PULLMAN, Wash. – Researchers led by a Washington State University biologist have found the optimal mechanism by which plants heal the botanical equivalent of a bad sunburn. Their work, published in th...