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Anew genetic variant that protects against Alzheimer’s disease has been identified by an international team led by Harvard Medical School investigators at Massachusetts General Hospital and Massachuse...
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development
birth defects developmental defects embryo folic acid high folate methylenetetrahydrofolate reductase MTHFD1 placenta
2018/12/19
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydro...
Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries
gene-diet interaction insulin resistance SFA:carbohydrate ratio S100A9 gene type 2 diabetes
2018/12/13
Background: S100 calcium-binding protein A9 (S100A9) has previously been identified as a type 2 diabetes (T2D) gene. However, this finding requires independent validation and more in-depth analyses in...
Ultrafast Excited-State Dynamics in the Green Fluorescent Protein Variant S65T/H148D.2.Unusual Photophysical Properties
Arabidopsis thaliana homogentisate phytyltransferase (HPT/VTE2) Lactuca sativa tocopherol tocopherol cyclase (TC/VTE1) vitamin e
2016/5/25
In the preceding accompanying paper [Shu, X., et al. (2007) Biochemistry 46, 12005-12013], the 1.5 A resolution crystal structure of green fluorescent protein (GFP) variant S65T/H148D is presented, an...
Ultrafast Excited-State Dynamics in the Green Fluorescent Protein Variant S65T/H148D.1.Mutagenesis and Structural Studies
Arabidopsis thaliana homogentisate phytyltransferase (HPT/VTE2) Lactuca sativa tocopherol tocopherol cyclase (TC/VTE1) vitamin e.
2016/5/24
Wild type green fluorescent protein (wt-GFP) and the variant S65T/H148D each exhibit two absorption bands, A and B, which are associated with the protonated and deprotonated chromophores, respectively...
Crystal Structure and Photodynamic Behavior of the Blue-emission Variant Y66H/Y145F of Green Fluorescent Protein
Animals Biological Transport Crystallography, X-Ray Green Fluorescent Proteins Hydrogen-Ion Concentration Luminescent Proteins Luminescent Proteins Luminescent Proteins Mutation Peptides Protein Folding Protons Scyphozoa Spectrometry,Fluorescence tructure-Activity Relationship Titrimetry
2016/5/23
The crystal structure of a blue emission variant (Y66H/Y145F) of the Aequorea victoria green fluorescent protein has been determined by molecular replacement and the model refined. The crystallographi...
Isoleucine-to-methionine substitution at residue 148 variant of PNPLA3 gene and metabolic outcomes in gestational diabetes
NAFLD PNPLA3 fatty liver iver enzymes GDM fatty liver ransaminase ALT trial
2018/12/20
Background: A single nucleotide polymorphism (SNP) of the patatin-like phospholipase-3 (PNPLA3)/adiponutrin gene (rs738409 C>G) is strongly associated with nonalcoholic fatty liver disease; to our kno...
Isoleucine-to-methionine substitution at residue 148 variant of PNPLA3 gene and metabolic outcomes in gestational diabetes
NAFLD PNPLA3 fatty liver liver enzymes GDM fatty liver transaminase ALT trial
2018/12/20
Background: A single nucleotide polymorphism (SNP) of the patatin-like phospholipase-3 (PNPLA3)/adiponutrin gene (rs738409 C>G) is strongly associated with nonalcoholic fatty liver disease; to our kno...
Spectral methods for bivariate Markov processes with diffusion and discrete components and a variant of the Wright-Fisher model
Bivariate Markov processes switching di usions matrix-valued orthogonal functions Wright-Fisher models
2011/9/14
Abstract: The aim of this paper is to study differential and spectral properties of the infinitesimal operator of two dimensional Markov processes with diffusion and discrete components. The infinites...
An international research team including researchers at UQ's Diamantina Institute and the Queensland Institute of Medical Research has identified a new variant of a gene that helps to regulate iron an...
Truthful mechanisms for two-range-values variant of unrelated scheduling
Truthful mechanism Approximation algorithm Scheduling
2012/11/30
In this paper, we consider a restricted variant of the scheduling problem, where the machines are the strategic players. For this multi-parameter mechanism design problem, the only known truthful mech...
Exploratory data analysis and clustering of multivariate spatial hydrogeological data by means of GEO3DSOM, a variant of Kohonen's Self-Organizing Map
self-organizing map Exploratory data analysis
2009/5/8
The use of unsupervised artificial neural network techniques like the self-organizing map (SOM) algorithm has proven to be a useful tool in exploratory data analysis and clustering of multivariate dat...
A Note on the Bezier Variant of Certain Bernstein Durrmeyer Operators
Lebesgue integrable functions Bernstein polynomials Bezier variant Functions of bounded variation
2008/7/3
In the present note, we introduce a Bezier variant of a new type of Bernstein Durrmeyer operator, which was introduced by Gupta [3]. We estimate the rate of convergence by using the decomposition tech...
A Variant of Jensen's Inequality.
A Variant of Jensen-Steffensen's Inequality for Convex and Superquadratic Functions
Jensen-Steffensen's inequality Monotonicity Superquadraticity Power means
2008/7/3
A variant of Jensen-Steffensen's inequality is considered for convex and for superquadratic functions. Consequently, inequalities for power means involving not only positive weights have been establis...