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LOCALLY D-OPTIMAL DESIGNS BASED ON A CLASS OF MODELS COMBINING AN EMAX AND ONE-COMPARTMENT MODELS∗
MODELS COMBINING AN EMAX ONE-COMPARTMENT MODELS∗
2015/3/18
A class of models combining a pharmacokinetic compartmental
model and a pharmacodynamic Emax model is introduced. One 4-
parameter and another 5-parameter models in this class are studied.
These mo...