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2024年7月14日,Trends in Biochemical Sciences杂志在线发表了中国科学院遗传与发育生物学研究所陆发隆研究组撰写的题为“Beyond simple tails: poly(A) tail-mediated RNA epigenetic regulation”的综述论文(DOI:10.1016/j.tibs.2024.06.013)。该论文总结了近年来关于RNA po...
线粒体的蛋白质组由细胞核和线粒体DNA(mtDNA)共同编码,维持线粒体与细胞核之间的交流对于线粒体的功能十分重要。衰老过程通常伴随着线粒体氧化磷酸化活性降低、TCA循环相关酶含量下降、mtDNA突变累积、活性氧增加,以及线粒体蛋白稳态的失衡。这些变化会影响线粒体与细胞核之间的交流,导致基因表达的变化并影响衰老进程。 线粒体不仅是能量代谢、生物合成的中心,其作为信号转导中心在调控细胞功...
2019年4月17日,北京大学生命科学学院、蛋白质与植物基因研究国家重点实验室成员陆剑研究员受邀在分子生物学综述类知名期刊《生物化学趋势》(Trends in Biochemical Sciences)发表题为“真核生物上游开放阅读框的功能与演化”(Function and Evolution of Upstream ORFs in Eukaryotes)的综述文章,总结了uORF的最新研究进展以...
This study was conducted to explore the outcomes of starvation/re-feeding techniques on growth performance, liver antioxidant activities, and histological changes of the gastrointestinal organs of Gan...
Electronic circuits are found in almost everything from smartphones to spacecraft and are useful in a variety of computational problems from simple addition to determining the trajectories of interpla...
A 51 bp section of the Rhodobacter capsulatus photosynthetic reaction center M subunit gene (nucleotides M562-M612 of the pufM structural sequence) encoding amino acids M187-M203 was replaced by the h...
Fatty acid elongation is the extension of de novo synthesized fatty acids through a series of four reactions analogous to those of fatty acid synthase. ELOs catalyze the first reaction in the elongati...
Genetic, biochemical, and biophysical methods have been adopted to characterize the interactions between ligand and transmembrane receptor, between receptor and cytoplasmic proteins, and between cytop...
Nucleosomes are the most fundamental unit of chromatin structure, which is composed of ~~145 bp of DNA wrapped around an octamer of core histones H2A, H2B, H3 and H4. Chromatin structure plays a role ...
Lysosomal storage diseases are disorders caused by deficiencies of enzymes responsible for the degradation of substances present in lysosomes. The loss of activity of a lysosomal enzyme leads to the a...
Several Lathyrus species and in particular Lathyrus sativus (grass pea) display much tolerance to drought and have great agronomic potential as grain and forage legumes. Studies on these crop species ...
Triplicate groups of fed and starved olive flounder, Paralichthys olivaceus (body weight: 119.8±17.46 g), were examined over 42 days for physiological changes using hematological, biochemical, and non...
The A-type lamin deficient mouse line (Lmna−/−) has become one of the most frequently used models for providing insights into many different aspects of A-type lamin function. To elucidate ...
近日,中国科学院生物化学与细胞生物学研究所/国家蛋白质科学中心·上海(筹)许琛琦研究员受邀在Cell 出版社综述期刊 Trends in Biochemical Sciences 上在线发表题为“Ionic protein-lipid interaction at the plasma membrane what can the charge do?”的科研综述,该综述论文总结了酸性磷脂领域的最新...
The effects of different dietary electrolyte balance (DEB) on growth performance, nitrogen (N) metabolism and some blood biochemical parameters were investigated in 2 to 3 months old growing rabbits. ...

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