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Probing the Peptidyl Transferase Center of Ribosomes Containing Mutant 23S rRNA with Photoreactive tRNA
ribosome peptidyl transferase center photoreactive crosslinking tRNA 23S rRNA translation
2014/12/9
There is strong crystallographic evidence that the 23S rRNA is the only catalytic entity in the peptidyl transferase center. Various mechanisms for the catalysis of peptidyl transfer have been propose...
Probing for Conformational Changes in the Repair Enzyme Mfd Using Mutant Protein Constructs
Conformational Changes Repair Enzyme Mfd Mutant Protein Constructs
2014/12/9
DNA repair is essential for survival, as damage to the genome can interrupt the precarious balance of cell functions, causing further mutations and possibly leading to cancer. The bacterial transcript...