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Scientists model outer membrane of 12 bacterial species to speed new drugs for 'bad bugs'
Scientists model membrane 12 bacterial species speed new drugs bad bugs
2016/11/4
As bacteria change their behavior to foil the drugs designed to kill them, illnesses that were once relatively easy to treat become difficult to cure. The phenomenon is known as antibiotic resistance,...
Dynamic Model Helps Understand Healthy Lakes to Heal Sick Ones
Dynamic Model Healthy Lakes Heal Sick Ones
2016/4/13
Development of a dynamic model for microbial populations in healthy lakes could help scientists understand what’s wrong with sick lakes, prescribe cures and predict what may happen as environmental co...
鉴定痢疾杆菌毒力基因的SW480细胞模型构建Construction of SW480 Cell Model Identifying Shigella Virulent Genes
SW480 细胞模型 痢疾杆菌 信号标签诱变技术 构建
2008/1/8
摘要
信号标签诱变技术（STM）是一种在体内高通量筛选病原体毒力基因的新方法，在应用时的一个先决条件是要建立合适的体内筛选系统。为将该技术应用于福氏痢疾杆菌，我们使用三个福氏痢疾杆菌菌株进行了预试验：通过同源重组构建而成的带有氯霉素抗性且aroA和virG基因失活的突变株RC426；因在侵袭质粒上自发缺失3个基因座(ipaBCDA, invA 和 virG)的另一减毒突变株T32，其曾被用作福氏...