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中国科学院研究揭示翻译调控型T-box核糖开关折叠与识别tRNA耦联的结构与动态机制（图）
翻译调控 识别 结构 分子动力学
2023/11/21
T-box核糖开关是一类位于革兰氏阳性细菌mRNA的 5'非翻译区的结构元件。它的长度通常在300核苷酸以下，可分为适配体结构域和表达平台结构域。T-box核糖开关通过其适配体结构域识别和结合特定的tRNA，并感知其3'末端的氨酰化状态，引发下游RNA元件构象状态的转变，进而在翻译水平或转录水平调控下游基因的表达。与其他核糖开关一般通过识别小分子代谢物或离子调控基因表达的机制不同，T-box基因表...
Seryl-tRNA Synthetases from Methanogenic Archaea: Suppression of Bacterial Amber Mutation and Heterologous Toxicity
seryl-tRNA synthetase heterologous toxicity amber suppression methanogenic archaea
2011/2/24
Methanogenic archaea possess unusual seryl-tRNA synthetases (SerRS), evolutionarily
distinct from the SerRSs found in other archaea, eucaryotes and bacteria. Our recent X-ray
structural analysis of ...
The in vivo Expression of Streptomyces rimosus tRNA Genes
Streptomyces rimosus expression promoter
2009/3/23
The expression of seven tRNA genes from Streptomyces rimosus, cloned on bifunctional plasmids, has been studied in a homologous (S. rimosus) and a heterologous (Escherichia coli) system. Analyzed gene...
Aminoacyl-tRNA Synthesis in Methanogenic Archaea
aminoacyl-tRNA methanogenic Archaea evolution tRNA translation
2009/3/20
Aminoacyl-tRNA synthetases (AARSs) are essential for faithful translation of the genetic code and have long been studied intensively. Major discoveries explained basic principles of how amino acids ar...
The Accuracy of Seryl-tRNA Synthesis
aminoacyl-tRNA synthetase tRNA-dependent amino acid recognition amino acid selection
2009/3/20
The high level of translational fidelity is ensured by various types of quality control mechanisms, which are adapted to prevent or correct naturally occurring mistakes. Accurate aminoacyl-tRNA synthe...