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二甲双胍作为最常用的降糖药物,已经被报道在多种肿瘤中可作为潜在的抗肿瘤药物。然而,由于二甲双胍的具体作用靶点不明确,极大地限制了我们对二甲双胍的理解和应用,并且二甲双胍在不同亚型的肿瘤中疗效并不相同。
Muscle protein that makes vertebrates more fit linked to limited lifespan
CaMKII vertebrate avoid diseases of old age oxidative stress
2021/8/6
Researchers say they have added to evidence that a protein called CaMKII improves strength, endurance, muscle health and fitness in young animals. Their experiments working with mice and fruit flies, ...
Deep dive into key COVID-19 protein is step toward new drugs, vaccines(图)
COVID-19 protein step toward new drugs vaccines
2021/4/23
Researchers at Oregon State University have taken a key step toward new drugs and vaccines for combating COVID-19 with a detailed biophysical study of one protein's interactions with the SARS-CoV-2 ge...
Key Residues of the Receptor Binding Motif in the Spike Protein of SARS-CoV-2 That Interact With ACE2 and Neutralizing Antibodies
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotens...
中国药科大学药学院姚静团队在Nano Letters报道Protein-Like自组装纳米转换体应用于肿瘤药物高效递送的最新研究成果(图)
中国药科大学药学院 姚静 Nano Letters 纳米药物 递送效率 肿瘤药物
2020/5/15
近日,材料学领域权威期刊Nano Letters(IF:12.279)在线发表了中国药科大学药学院姚静教授团队的最新研究成果——Transforming Complexity to Simplicity: Protein-Like Nanotransformer for Improving Tumor Drug Delivery Programmatically(https://dx.doi.or...
SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells
SARS-CoV-2-encoded nucleocapsid protein acts viral suppressor of RNA interference cells
2020/6/12
We thank Prof. Peng Zhou (Wuhan, China) for kindly providing materials and thank Yan Wu and Weijuan Shang for experimental assistance. This work was supported by the Strategic Priority Research Progra...
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
2019-nCoV SARS-CoV ACE2 monoclonal antibody RBD
2020/6/12
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, how...
Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
Fusion mechanism 2019-nCoV inhibitors targeting HR1 domain spike protein
2020/6/12
Very recently, a novel coronavirus, 2019-nCoV, emerged in Wuhan, China and then quickly spread worldwide, resulting in >17,388 confirmed cases and 361 deaths as of 3 February 2020, thus calling for th...
An Anti-Aging Protein Could Be Targeted to Rejuvenate Immune Cells
Anti-Aging Protein Rejuvenate Immune Cells
2017/12/19
Anti-aging proteins have long been shown to protect against age-related diseases, such as cancer, neurodegeneration, and cardiovascular disease. A study by researchers at the Gladstone Institutes now ...
Effects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women
aging appetite and energy intake gastrointestinal function gastrointestinal mechanisms sex whey protein
2018/11/19
Background: Protein- and energy-rich supplements are used widely for the management of malnutrition in the elderly. Information about the effects of protein on energy intake and related gastrointestin...
Effects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women
aging appetite and energy intake gastrointestinal function gastrointestinal mechanisms sex whey protein
2018/11/16
Background: Protein- and energy-rich supplements are used widely for the management of malnutrition in the elderly. Information about the effects of protein on energy intake and related gastrointestin...
2017蛋白-RNA相互作用 Keystone Symposia(2017 Keystone Symposia on Protein-RNA Interactions)
Protein RNA
2017/1/17
The meeting will begin on Sunday, February 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 9 with a closing plenary se...
Nanopolymer-modified protein array can pinpoint hard-to-find cancer biomarker
Nanopolymer-modified protein array cancer biomarker
2016/11/29
A Purdue University biochemist has developed a novel method for detecting certain types of proteins that serve as indicators for cancer and other diseases.
Glycoproteins are formed when sugars attach...