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首都医科大学附属北京天坛医院江涛院士团队《Sig Transduct Target Ther》阐述CAR分子胞啃作用介导的CAR-T细胞失活与肿瘤抗原逃逸机制（图）
首都医科大学 北京天坛医院 肿瘤
2024/7/12
近日，首都医科大学附属北京天坛医院神经外科学中心江涛院士/张伟教授团队在《Sig Transduct Target Ther》在线发表题为“Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape”的封面研究论文。不同于以往研究报道的淋巴细胞作为“受者”获取肿瘤细胞抗原的经典胞啃现象...
孔德新教授课题组Signal Transduct Target Ther报道：Stellettin B协同PARP抑制剂抗胶质母细胞瘤的作用及分子机制（图）
孔德新教授 天津医科大学 抑制剂
2023/7/8
天津医科大学药学院孔德新教授课题组近期在Signal Transduct Target Ther（IF=38.104）发表题为“Stellettin B renders glioblastoma vulnerable to poly (ADP-ribose) polymerase inhibitors via suppressing homology-directed repair”的文章，报道了...
Cancer is characterized by a number of key biological processes known as the “hallmarks of cancer,” which remodel cells and their immediate environment so that tumors can form, grow, and thrive. Many ...
中南大学湘雅公共卫生学院黄瑞雪课题组在Signal Transduct Target Ther上发表论文（图）
中南大学湘雅公共卫生学院 黄瑞雪 Signal Transduct Target Ther 放射治疗 肿瘤治疗
2020/7/12
近日，中南大学湘雅公共卫生学院黄瑞雪课题组在Nature出版集团旗下期刊Signal Transduct Target Ther (IF:13.493)上在线发表了题为“DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer”的综述文章。
New probe developed to detect a common target for anti-inflammatory drugs（图）
New probe developed detect common target anti-inflammatory drugs
2020/3/6
Scientists have developed a probe named CoxFluor that can distinguish between Cyclooxygenase-2, an enzyme that plays a major role in driving the progression of cancer, and the enzyme Cyclooxygenase-1,...
P53 “master switch” remains top target in gene signaling network controlling cancer suppression（图）
P53 master switch top target gene signaling network controlling cancer suppression
2017/10/25
There are two important categories of genes involved in cancer development, oncogenes and tumor suppressor genes. When oncogenes gain function, e.g. through mutation, they actively promote cancer – dr...
UA Cancer Center Team Identifies a Switch that May Help Target Dormant Cancer Cells（图）
UA Cancer Center Team Dormant Cancer Cells
2017/10/24
A study by scientists at the University of Arizona and the University of Pittsburgh may hold the key to targeting dormant — or inactive —cancer cells, which are resistant to chemotherapy and other tre...
X-Ray Study Reveals Long-Sought Insights Into Potential Drug Target
X-Ray Long-Sought Insights Potential Drug Target
2017/4/27
X-ray studies done in part at the Department of Energy’s SLAC National Accelerator Laboratory have produced surprising insights into the workings of a hormone receptor associated with blood pressure r...
Novel microwave-induced photodynamic therapy could target deeply situated tumors
Novel microwave-induced photodynamic therapy deeply situated tumors
2016/11/4
Physicists at The University of Texas at Arlington have shown that using microwaves to activate photosensitive nanoparticles produces tissue-heating effects that ultimately lead to cell death within s...
Inhibition of Ape1's DNA Repair Activity as a Target in Cancer: Identification of Novel Small Molecules that have Translational Potential for Molecularly Targeted Cancer Therapy
Cancer Chemotherapy Base Excision Repair DNA Repair
2015/5/25
The DNA Base Excision Repair (BER) pathway repairs DNA damaged by endogenous and exogenous agents including chemotherapeutic agents. Removal of the damaged base by a DNA glycosylase creates an apurini...
TSRI Scientists Discover Possible New Target for Treating Brain Inflammation
TSRI Scientists Treating Brain Inflammation
2015/1/20
This treatment approach may also turn out to be useful against more common conditions that involve brain inflammation—a category that includes multiple sclerosis, Alzheimer’s, Parkinson’s, ALS and sec...
Repression of cyclin D1 as a target for germ cell tumors
metastatic germ cell tumors cyclin D1
2014/12/12
Metastatic germ cell tumors (GCT) are curable, however GCTs refractory to cisplatin-based chemotherapy have a poor prognosis. This study explores D-type cyclins as molecular targets in GCTs because al...
Cloning of the Recombinant Cytochrome P450 Cyp141 Protein of Mycobacterium tuberculosis as a Diagnostic Target and Vaccine Candidate
Cloning Cytochrome Mycobacterium Tuberculosis Diagnostic
2015/10/15
Background: Tuberculosis has been announced as a global emergency by World Health Organization and the second infectious agent of mortality worldwide. The general policy in the development of new vacc...
Single-Nucleotide Polymorphisms Within MicroRNAs Sequences and Their 3' UTR Target Sites May Regulate Gene Expression in Gastrointestinal Tract Cancers
MicroRNAs Gastrointestinal Neoplasms Colorectal Neoplasms Gastric Neoplasms
2015/10/13
Background: Esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (GIT) neoplasms, causing almost two million deaths worldwide each year. some environmental risk facto...
University of Queensland scientists have discovered that a protein that regulates how tall people grow could be used in treating diseases including cancer and diabetes.