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清华大学医学院向烨课题组在Plos Pathogen杂志发表题为“Structural intermediates in the low pH-induced transition of influenza hemagglutinin”的研究论文（图）
清华大学医学院 向烨课题组 Plos Pathogen 杂志 Structural intermediates in the low pH-induced transition of influenza hemagglutinin 研究论文
2020/12/30
2020年11月30日，清华大学医学院向烨课题组在Plos Pathogen杂志发表了题为“Structural intermediates in the low pH-induced transition of influenza hemagglutinin”的研究论文。流感病毒（Influenza virus）是人类常见且极具威胁性的病原体之一，可引起季节性或流行性感冒。因为流感病毒的快速突变...
Structural basis for RNA replication by the SARS-CoV-2 polymerase
2019-nCoV SARS-CoV-2 COVID-19 remdesivir favipiravir polymerase RdRP virus nsp12 nsp8
2020/6/11
Nucleotide analog inhibitors, including broad-spectrum remdesivir and favipiravir, have shown promise in in vitro assays and some clinical studies for COVID-19 treatment, this despite an incomplete me...
Structural Basis for the Inhibition of SARS-CoV-2 Main Protease by Antineoplastic Drug Carmofur
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of...
2017年分子，结构和功能成像生物医学应用研讨会（Biomedical Applications in Molecular, Structural, and Functional Imaging）
Molecular Structural Functional Imaging
2017/1/20
Posters will be on display Sunday and Monday with extended viewing until 9:00 pm on Sunday. The interactive poster session with authors in attendance will be Monday evening from 5:30 to 7:00 pm. Award...
A deep learning framework for modeling structural features of RNA-binding protein targets
learning framework modeling structural features RNA-binding protein targets
2016/1/22
RNA-binding proteins (RBPs) play important roles in the post-transcriptional control of RNAs. Identify-ing RBP binding sites and characterizing RBP bind-ing preferences are key steps toward understand...
Structural and Contextual Dimensions of Iranian Primary Health Care System at Local Level
Health Services Administration Organizational Structure Organizational Culture
2015/10/16
Background: In recent years, family physician plan was established as the main strategy of health system in Iran, while organizational structure of the primary health care system has remained the same...
Ventricular Tachycardia in the Absence of Structural Heart Disease
Ventricular tachycardia structurally normal heart
2015/8/5
In up to 10% of patients who present with ventricular tachycardia (VT), obvious structural heart disease is not identified. In such patients, causes of ventricular arrhythmia include right ventricular...
Identification, kinetic and structural characterization of small molecule inhibitors of aldehyde dehydrogenase 3a1 (Aldh3a1) as an adjuvant therapy for reversing cancer chemo-resistance
cyclophosphamide chemosensitivity structure activity relationships cell culture
2015/5/25
ALDH isoenzymes are known to impact the sensitivity of certain neoplastic cells toward cyclophosphamides and its analogs. Despite its bone marrow toxicity, cyclophos-phamide is still used to treat var...
Variable selection and structural discovery in joint models of longitudinal and survival data
Joint models Mixed effect selection Structural discovery Adaptive LASSO Gaussian quadrature EM algorithm
2015/5/21
Joint models of longitudinal and survival outcomes have been used with increasing frequency in clinical investigations. Correct specification of fixed and random effects, as well as their functional f...
Step-growth thiol-ene photopolymerization to form degradable, cytocompatible and multi-structural hydrogels
hydrogel biomaterial degradation multi-structure photopolymerization thiol-ene chemistry
2015/1/12
Hydrogels prepared from photopolymerization have been used for a variety of tissue engineering and controlled release applications. Polymeric biomaterials with high cytocompatibility, versatile degrad...
Effects of tissue hydration on nanoscale structural morphology and mechanics of individual Type I collagen fibrils in the Brtl mouse model of Osteogenesis Imperfecta
AFM Ultrastructure Genotype/phenotype D-periodic spacing Modulus Energy
2014/11/6
Type I collagen is the most abundant protein in mammals, and is a vital part of the extracellular matrix for numerous tissues. Despite collagen’s importance, little is known about its nanoscale morpho...
Historical, tactical and structural analysis of the 4:2 defensive play system in handball
HANDBALL DEFENSIVE PLAY SYSTEM DEVELOPMENT TACTICS
2013/10/1
This study aims to show how the 4-2 Defensive Play System in Handball has developed both tactically and structurally over time. Logically, since its first appearance in Czechoslovakia during the 1960s...
HIV prevention: Towards a “structural-plus” approach
HIV Prevention Structural Factors Development
2013/1/29
Lack of integration and coordination between HIV prevention programmes and developmental programmes explain why many countries have not been able to halt the epidemic, and others still have unacceptab...
Structural neuroimaging and neuropsychological correlates of a single case of focal central pontine myelinolysis: Intact memory function with decreased intellectual and motor functions
Central Pontine Myelinolysis Neuropsychology
2013/2/20
We report on the case of middle-aged right-handed woman with central pontine myelinolysis (CPM) revealed by high resolution structural T2-weighted FLAIR MRI imaging. There was a general flattening of ...
Nature Structural & Molecular Biology发表中国科学院生物物理研究所肉碱膜转运蛋白CaiT三维结构研究成果（图）
Nature Structural & Molecular Biology 膜转运蛋白CaiT
2010/4/1
2010年3月28日，生物物理研究所江涛研究员课题组在 Nature Structural & Molecular Biology杂志在线发表了题为“Crystal Structure of the Carnitine Transporter and Insights into the Antiport Mechanism ”的文章。该研究解析了肉碱膜转运蛋白CaiT的三维结构，并对其分子机制进行...