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Lack of EGF receptor contributes to drug sensitivity of human germline cells
DNA damage epidermal growth factor receptor drug resistance
2014/12/12
Germline mutations have been associated with generation of various types of tumour. In this study, we investigated genetic alteration of germline tumours that affect the drug sensitivity of cells. Alt...
Protection of Human Lung Cells against Hyperoxia Using the DNA Base Excision Repair Genes hOgg1 and Fpg
oxygen toxicity DNA damage DNA repair
2014/12/12
Hyperoxia causes pulmonary toxicity in part by injuring alveolar epithelial cells. Previous studies have shown that toxic oxygen-derived species damage DNA and this damage is recognized and repaired b...
Conversion of the Bifunctional 8-oxoguanine/β-δ AP DNA Repair Activities of Drosophila Ribosomal Protein S3 into the Human S3 Monofunctional β- elimination Catalyst Through a Single Amino Acid Change
DNA repair drosophila ribosomal protein s3
2014/12/12
The Drosophila S3 ribosomal protein has important roles in both protein translation and DNA repair. In regards to the latter activity, it has been shown that S3 contains vigorous N-glycosylase activit...
A novel fluorometric oligonucleotide assay to measure O 6-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase
APE1/Ref-1 DNA repair status
2014/12/12
DNA repair status plays a major role in mutagenesis, carcinogenesis and resistance to genotoxic agents. Because DNA repair processes involve multiple enzymatic steps, understanding cellular DNA repair...
The Effect of Human Recombinant Erythropoietin on Prevention of Anemia of Prematurity
Neonate Anemia Prematurity Erythropoietin Anemia prevention
2010/4/20
Objective: Premature infants often develop significant anemia that requires blood transfusion, this carries significant risks. This study was carried out to determine the effect of recombinant human e...
Eraly Treatment of Anemia of Prematurity with Recombinant Human Erythropoietin
anemia of prematurely erythropoietin treatment
2015/9/7
Background: Recombinant Human Erythropoietin (EPO) is known to accelerate erythropoesis in preterm infants. This study was designed to access of EPO in treatment of anemia of prematurity.
Materials a...
IL-13 GENE TRANSLATION IS ARRESTED BY A NOVEL OLIGONUCLEOTIDE IN CULTURED HUMAN B- LYMPHOCYTES
Antisense Human IL-13
2010/4/26
Antisense oligodeoxynucleotides (oligos) are the tools that bind to complemen¬tary sequence of targeted mRNA and block specifically protein translation. In the present study, a novel 20 mer oligo ...