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浙江大学医学院孙启明课题组在《Molecular Cell》发文揭示自噬体成熟和脂代谢调控的新机制（图）
浙江大学医学院 孙启明 课题组 Molecular Cell 自噬体成熟 脂代谢
2019/2/25
2019年1月28日，浙江大学医学院孙启明课题组在Molecular Cell在线发表了题为Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism 的文章，该工作阐明了脊椎生物特有的自噬调控基因Pacer如何感知上游营养...
Effect of hypoenergetic feeding and refeeding on muscle and mononuclear cell activities of mitochondrial complexes I–IV in enterally fed rats
mitochondrial complexes I–IV electron transport chain rats
2016/6/13
Previous studies suggested that cell energetics are
altered by malnutrition.
Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n−3 or n−6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y
Fish oil immunity natural killer cell
2016/6/12
Animal studies showed that dietary flaxseed oil
[rich in the n3 polyunsaturated fatty acid -linolenic acid
(ALA)], evening primrose oil [rich in the n6 polyunsaturated
fatty acid -linolenic acid (...
Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n−3 fatty acids
sudden cardiac death cardiac arrest ventricular arrhythmias
2016/6/1
Dietary intake of long-chain n23 polyunsaturated
fatty acids (PUFA) may protect against sudden cardiac
death, an event that may be predicted by measurement of heart
rate variability (HRV).
Influence of prenatal iron and zinc supplements on supplemental iron absorption, red blood cell iron incorporation, and iron status in pregnant Peruvian women
Stable isotopes iron zinc
2016/5/30
We aimed to examine the influence of iron status on
iron absorption during pregnancy by measuring supplemental
iron absorption, red blood cell iron incorporation, and iron status
in pregnant women.
Serum and red blood cell folate concentrations, race, and education: findings from the third National Health and Nutrition Examination Survey
Education ethnic group folic acid
2016/5/30
Little is known about the relations between race or
ethnicity, educational attainment, and serum and red blood cell folate
concentrations.
2015年8月5日，国际学术期刊Cell Research 封面文章介绍了我所段胜仲研究组的最新研究成果"High salt primes a specific activation state of macrophages, M(Na)"。该研究发现了具有独特活化状态的巨噬细胞“M(Na)”，揭示高盐饮食是肺部急性炎症的风险因素之一。
长期摄入高盐食物能增加心血管疾病、肥胖、2型糖尿病以及自身...
Influence of nutrient intake on antioxidant capacity, muscle damage and white blood cell count in female soccer players
Immune response Inflammation Antioxidant enzymes
2015/7/23
Soccer is a form of exercise that induces inflammatory response, as well as an increase in free radicals
potentially leading to muscle injury. Balanced nutritional intake provides important antioxida...
Cell damage, antioxidant status, and cortisol levels related to nutrition in ski mountaineering during a two-day race
Energy intake micronutrients muscle damage
2015/5/5
The aim of this study was to measure the effect of nutrition on
cell damage, antioxidant enzymes, and cortisol during a two-day
ski mountaineering competition.
Calculation of red blood cell folate steady state conditions and elimination kinetics after daily supplementation with various folate forms and doses in women of childbearing age
Red blood cell folate steady state elimination kinetics neural tube defects
2008/12/22
Background: A maternal red blood cell (RBC) folate concentration > 906 nmol/L is thought to be optimal for lowering the risk of neural tube defects (NTDs) in pregnancy. Whereas the appearance of f...
Arachidonic acid–and docosahexaenoic acid–enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets
Arachidonic acid docosahexaenoic acid immunity growth piglets
2008/12/12
Background: Whereas the immunomodulatory effects of feeding either arachidonic acid (AA) or docosahexaenoic acid (DHA) separately have been previously investigated, little is known about the immunomod...
Dietary pattern in association with squamous cell carcinoma of the skin: a prospective study1,2,3
Dietary patterns skin cancer squamous cell carcinoma risk basal cell carcinoma risk principal components analysis
2008/12/12
Background: The role of diet in the development of skin cancer is inconclusive, and the effect of the combined consumption of foods has never been reported.Objective: We prospectively investigated the...
In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer
lactase treatment vitro digestion
2008/4/23
Quercetin and quercetin glycosides are widely consumed flavonoids found in many fruits and vegetables. These compounds have a wide range of potential health benefits, and understanding the bioavailabi...
Severe malnutrition with and without HIV-1 infection in hospitalised children in Kampala, Uganda: differences in clinical features, haematological findings and CD4+ cell counts
HIV-1 Severe malnutrition
2008/4/23
The aim of this study was to describe the clinical features, haematological findings and CD4+ and CD8+ cell counts of severely malnourished children in relation to human immunodeficiency virus (HIV) i...
Membrane peroxidation by lipopolysaccharide and iron-ascorbate adversely affects Caco-2 cell function: beneficial role of butyric acid
Iron-ascorbate membrane fluidity permeability
2016/12/30
We examined the effects of lipopolysaccharide (LPS), a ubiquitous endotoxin mediator of gram-negative bacteria, alone and in combination with iron-ascorbate, on enterocyte function. Furthermore, we as...